TOP-5 studies on nutrients and orthomolecular medicine from 02.07.2026 - 09.07.2026
Vitamin D in multiple sclerosis as adjunctive therapy: network meta-analysis of randomized controlled trials; Acceptability of school and home micronutrient supplementation and nutrition education program among adolescents in Mozambique; Five-year outcomes after single-anastomosis duodenoileal bypass (SADI) compared to biliopancreatic diversion with duodenal switch (BPD/DS): randomized clinical trial; Dysregulation of copper in cardiometabolic diseases: copper deficiency versus cuproptosis; Pediatric post-acute sequelae of SARS-CoV-2 infection in Taiwan: data from the DISCOVER cohort.
5. Vitamin D in multiple sclerosis as adjunctive therapy: network meta-analysis of randomized controlled trials.
About the work.
The study aimed to evaluate the efficacy and safety of adding vitamin D to standard therapy in patients with multiple sclerosis. The conducted network meta-analysis compared vitamin D with placebo and standard treatment.
Results.
The analysis of 32 RCTs showed that long-term use of vitamin D significantly reduces the risk of relapses (RR 0.80) and improves EDSS scores (MD -0.22). High doses of vitamin D demonstrated the greatest efficacy for EDSS (MD -0.28) and relapses (RR 0.76) compared to placebo. The safety of vitamin D was at a level with no significant differences in serious adverse events (RR 1.49).
4. Acceptability of micronutrient supplementation and nutrition education program for adolescents in schools and homes in Mozambique.
About the work.
The study aimed to assess the acceptability of a multi-component micronutrient supplement (MMS) and iron-folic acid supplement (IFAS) among adolescents in Mozambique. Reactions to the contextualized nutrition program implemented through school clubs were also evaluated.
Results.
IFAS was significantly more acceptable than MMS in terms of smell, and some participants found the once-weekly IFAS regimen less burdensome than the daily MMS. Participants in both groups reported increased energy, improved appetite, and relief from menstrual symptoms. Positive evaluations of the nutrition program and teachers' work were received in both groups. Participants generally preferred their assigned regimen, and family support contributed to adherence.
3. Five-year outcomes after single-anastomosis duodenoileal bypass (SADI) compared to biliopancreatic diversion with duodenal switch (BPD/DS): randomized clinical trial.
About the work.
The study compared outcomes five years after two surgical interventions: single-anastomosis duodenoileal bypass (SADI) and biliopancreatic diversion with duodenal switch (BPD/DS) in patients with a body mass index over 45 kg/m².
Results.
The average percentage of weight loss after five years was 34.3% after SADI and 36.7% after BPD/DS, with the difference not being statistically significant. 12 out of 56 participants underwent at least one reoperation, with cases of internal hernia and surgery related to malnutrition observed only after BPD/DS. Vitamin D deficiency was more prevalent after BPD/DS (40.9% vs. 12.5% after SADI; p = 0.037).