TOP-5 studies on keto, low-carbohydrate diets, and intermittent fasting from July 20, 2026 - July 27, 2026
A study on the feasibility, acceptability, and safety of a 4:3 intermittent fasting program for weight loss among overweight or obese breast cancer survivors stage I-III; A new role of trace elements in epilepsy and metabolic disorders: a new frontier in neurotherapy; Infantile epilepsy with migrating focal seizures: a review of clinical features, diagnostic testing including genetics, long-term outcomes, mortality, and current and emerging therapeutic strategies; Alternate fasting; A case of exercise-induced paroxysmal dyskinesia expands the phenotypic spectrum of -gene-related encephalopathy.
5. A study on the feasibility, acceptability, and safety of a 4:3 intermittent fasting program for weight loss among overweight or obese breast cancer survivors stage I-III: protocol for a 6-month concept trial.
About the work.
The study aims to evaluate the feasibility, acceptability, and safety of a weight loss program using 4:3 intermittent fasting for breast cancer survivors with overweight or obesity. The study will also examine clinical outcomes such as body weight and dietary adherence.
Results.
The available abstract describes the results insufficiently.
4. A new role of trace elements in epilepsy and metabolic disorders: a new frontier in neurotherapy.
About the work.
The study examines the relationship between trace element status and disease variability, particularly epilepsy. It discusses the mechanisms by which various metals influence epileptic seizures and their association with hereditary metabolic disorders.
Results.
Available data suggest that dysregulation of trace elements may affect epileptogenesis, seizure susceptibility, and response to antiepileptic therapies.
3. Infantile epilepsy with migrating focal seizures: a review of clinical features, diagnostic testing including genetics, long-term outcomes, mortality, and current and new therapeutic strategies.
About the work.
The aim of the study was to systematically investigate the clinical, electrophysiological, neuroimaging, genetic, and therapeutic aspects of infantile epilepsy with migrating focal seizures (IEMFS). The analysis focused on published data that reveal key knowledge gaps and priorities for future research.
Results.
Of the 643 selected articles, 89 met the inclusion criteria. The classical electro-clinical phenotype was confirmed; however, significant gaps were identified: stratification by genetic etiology for neonatal and post-neonatal onset remains largely uncharacterized; genotype-specific EEG biomarkers are absent, except for one small study on KCNT1; the clinical significance of atypical EEG features has not been determined.
2. Alternate fasting increases leptin sensitivity through JMJD3-dependent epigenetic regulation of the leptin receptor in the hypothalamus.
About the work.
The study aims to evaluate the effect of alternate fasting on leptin sensitivity in obese mice. Changes in leptin receptor expression in the hypothalamus and metabolic parameters were compared during alternate fasting.
Results.
ADF significantly enhanced leptin-induced reductions in food intake and body weight, increasing STAT3 phosphorylation in the hypothalamus. ADF led to decreased repressive H3K27 methylation at the LepRb promoter, contributing to increased LepRb expression in the hypothalamus.