TOP-5 Studies on Obesity, Diabetes, and Insulin Resistance from 08.18.2026 - 08.25.2026
Assessment of the safety and efficacy of sodium pentaborate pentahydrate in overweight and obese individuals: a randomized, double-blind, placebo-controlled phase 1/2 dose-finding study; The impact of organic selenium supplementation on glycemic control and quality of life in patients with diabetic neuropathy: a randomized controlled trial with placebo; Perimenopause and metabolic vulnerability: hormones, body composition, and lifestyle changes; The effect of microbiome-modulating therapies on anthropometric and hemodynamic biomarkers in metabolic syndrome: a systematic review, meta-analysis, and meta-regression of clinical trials; Glucose metabolism in osteoporosis: a potential therapeutic target (Review).
5. Assessment of the safety and efficacy of sodium pentaborate pentahydrate in overweight and obese individuals: a randomized, double-blind, placebo-controlled phase 1/2 dose-finding study.
About the study.
The study aims to assess the short-term safety and tolerability of sodium pentaborate pentahydrate in overweight and obese individuals, as well as to provide preliminary efficacy data. A total of 177 adults participated in the randomized double-blind placebo-controlled study, of which 116 completed the 12-week intervention.
Results.
The average body weight decreased in the 400 mg (-2.6 kg), 600 mg (-1.2 kg), and 1,000 mg (-3.1 kg) groups. The 1,000 mg dose resulted in the greatest weight loss (mean difference, -2.30 kg; p = 0.01) and body mass index reduction (mean difference, -0.85 kg/m2; p = 0.02). All reported adverse effects were mild.
4. The impact of organic selenium supplementation on glycemic control and quality of life in patients with diabetic neuropathy: a randomized controlled trial with placebo.
About the study.
The study aims to evaluate the effect of organic selenium on glycemic control and quality of life in patients with diabetic neuropathy. The randomized placebo-controlled trial involved 50 patients with type 2 diabetes and confirmed diabetic neuropathy.
Results.
Selenium supplementation significantly reduced fasting glucose and glycated hemoglobin levels, as well as improved insulin sensitivity in patients with type 2 diabetes and diabetic neuropathy.
3. Perimenopause and metabolic vulnerability: hormones, body composition, and lifestyle changes.
About the study.
The study focuses on perimenopause as a critical stage of metabolic vulnerability in women, characterized by hormonal changes and alterations in body composition. It discusses the implications of decreased estrogen levels and the impact of lifestyle on metabolic health.
Results.
Perimenopause is associated with increased visceral fat, loss of muscle mass, decreased fat oxidation, and impaired metabolic flexibility, even without significant weight changes. Decreased estrogen levels lead to fat redistribution, muscle dysfunction, hepatic insulin resistance, and chronic low-grade inflammation, increasing the risk of metabolic syndrome, type 2 diabetes, and cardiovascular events.