TOP-5 studies on biohacking and longevity from 04.09.2026 to 11.09.2026
Subcellular signaling networks of sirtuins: key regulators of cardiovascular homeostasis and remodeling; Similarities and differences between extravascular and subcutaneous implantable cardioverter-defibrillators: clinical selection and implantation (Part 1); Chronic pain in middle age; How to live for centuries: common characteristics of organisms with exceptional longevity; Protein consumption throughout life: optimizing health, function, and longevity.
5. Subcellular signaling networks of sirtuins: key regulators of cardiovascular homeostasis and remodeling.
About the work.
The aim of the study is to systematically investigate the roles of sirtuins in maintaining cardiovascular homeostasis. The analysis focuses on the molecular mechanisms regulating inflammation and vascular remodeling.
Results.
Sirtuins play a key role in protecting against cardiovascular remodeling, atherosclerosis, and heart failure by modulating macrophage polarization and reducing vascular inflammation through the NF-κB signaling pathway. Sirtuin-based strategies are proposed for the treatment of acute and chronic cardiovascular diseases.
4. Similarities and differences between extravascular and subcutaneous implantable cardioverter-defibrillators: clinical selection and implantation (Part 1).
About the work.
This review discusses two platforms of implantable cardioverter-defibrillators without transvenous access: subcutaneous (S-ICD) and extravascular (EV-ICD). It examines patient selection and implantation aspects.
Results.
Long-term trial data confirm the reliability of S-ICD defibrillation without invasive leads, with lower rates of lead failures, infections, and pneumothorax compared to transvenous systems. The EV-ICD demonstrated effective defibrillation and anti-tachycardia pacing in approximately 77% of cases.
3. Chronic pain in middle age.
About the work.
This study focuses on chronic pain in women during menopause, including the impact of reproductive changes and biopsychosocial factors on pain manifestation. Common chronic pain syndromes and the need for an integrated approach to their treatment are discussed.
Results.
Approximately half of middle-aged women experience chronic pain, often with overlapping syndromes such as fibromyalgia and migraine. Chronic pain is a significant health issue, often underestimated and underdiagnosed.
2. How to live for centuries: common characteristics of organisms with exceptional longevity.
About the work.
This study aims to understand the differences in lifespan among organisms, particularly among species living over 250 years. It examines the mechanisms regulating both intraspecific and interspecific variation in lifespan.
Results.
Similarities in mechanisms related to DNA maintenance, stem cells, and stress management were identified, which are characteristic of both intraspecific and interspecific lifespan variation.