Synergy of Vitamins D and K in Supporting Immunity on Low-Carbohydrate Diets

On September 21, 2025, an article was published revealing the significance of the synergistic effect of vitamins D and K when following low-carbohydrate diets, including the keto diet.

The authors of the study note that the combined intake of vitamins D and K helps optimize immune function and reduce inflammatory processes in the body. These findings confirm the growing interest in orthomolecular support for the keto diet aimed at minimizing potential side effects associated with carbohydrate restriction.

The keto diet is characterized by a significant reduction in carbohydrate intake, which limits the intake of not only fiber but also a number of important vitamins and minerals, including vitamin D. It is known that during the autumn-winter period, the production of vitamin D by the skin significantly decreases, especially in regions with a lack of sunny days. This increases the risk of deficiency, which negatively affects metabolism, immunity, and overall well-being.

Vitamin D plays a key role in regulating calcium and phosphorus metabolism, maintaining bone health, and also possesses anti-inflammatory properties. In combination with vitamin K, it helps direct calcium into bone tissue, preventing its deposition in blood vessels and minimizing the risk of inflammation.

The use of dietary supplements with vitamins D3 and K is especially recommended on low-carbohydrate diets for:

• Supporting the immune system;
• Maintaining bone and vascular health;
• Reducing the risk of autoimmune and inflammatory diseases.

Experts recommend regularly monitoring vitamin D levels in the blood and, if necessary, taking supplements containing cholecalciferol (vitamin D3), as well as additionally including vitamin K to enhance the effect and safety of therapy.

This comprehensive dietary and support scheme works to prevent the negative consequences of the diet and contributes to improving overall health.