New Data: Coenzyme Q10 and L-Carnitine Support Mitochondria on the Keto Diet in 2025

In 2025, new scientific data emerged confirming the benefits of orthomolecular supplements for supporting mitochondria in individuals following a ketogenic diet. In particular, coenzyme Q10 and L-carnitine are used to enhance energy metabolism and reduce fatigue.

The ketogenic diet is a high-fat, low-carbohydrate eating plan aimed at transitioning the body into a state of ketosis. In this state, fats become the primary source of energy, which requires high mitochondrial activity — the "power stations" of the cell. Despite the diet's effectiveness for weight loss and metabolic improvement, the transitional adaptation period is often associated with fatigue and a decrease in overall tone.

Recent studies from 2025 show that the intake of coenzyme Q10, an important cofactor in the mitochondrial electron transport chain, and L-carnitine, which is involved in the transport of fatty acids into the mitochondria, can significantly enhance energy metabolism efficiency. This helps reduce fatigue symptoms, improve endurance, and enhance the quality of life for patients on a keto diet.

Key Principles of the Ketogenic Diet

• Drastic reduction of carbohydrates (to 20-50 g per day)
• High fat intake (about 70-80% of calories)
• Moderate protein intake (approximately 15-20%)
• Transition of the body into a state of ketosis — active fat burning for energy

The first few days on the keto diet may be accompanied by temporary manifestations known as "keto flu," including fatigue and decreased energy, which are related to the restructuring of cellular metabolism.

Role of Orthomolecular Agents

Coenzyme Q10 and L-carnitine are used to enhance mitochondrial function, ensuring optimal energy metabolism. Their addition to the ketogenic therapy diet can not only improve diet tolerability but also increase its therapeutic effectiveness, especially in patients with chronic fatigue and heightened energy needs.

Thus, modern orthomolecular approaches represent a promising direction in the comprehensive support of patients on a ketogenic diet and contribute to improving overall well-being and increasing energy levels.