Magnesium is involved in processes that may indirectly promote the release of arsenic. It participates in glutathione metabolism, in methylation (via SAMe), and in enzymatic systems that ensure detoxification.
Both zinc and selenium are cofactors of antioxidant enzymes (such as glutathione peroxidase, superoxide dismutase) and also support the function of methylation enzymes necessary for converting inorganic arsenic into organic forms (mono- and dimethylarsinic acid), which are more easily excreted in urine.
When these minerals are introduced, mobilization of arsenic from tissues into the bloodstream may occur, sometimes temporarily increasing its concentration in plasma. This is a normal part of the mobilization phase before the excretion phase.
After mobilization, effective excretion through the liver, kidneys, and bile should occur—through methylation, binding with glutathione, and subsequently through urine and feces.
In individuals with impaired methylation (for example, MTHFR polymorphism), this process may proceed poorly.
If the detoxification system is overloaded or depleted, mobilization of arsenic without effective excretion can lead to exacerbation of intoxication. Therefore, during any active removal of heavy metals, it is important to maintain hydration, liver enzymes, methylation (B9, B12, SAMe), and glutathione levels (for example, NAC).
