New Data from 2025: How the Ketogenic Diet Affects the Gut Microbiome and Overall Health

Recent studies from 2025 provide deeper insights into the impact of the ketogenic diet on the gut microbiome and human health. The latest findings confirm that ketosis, resulting from low carbohydrate intake and increased fat metabolism, contributes to changes in the composition of gut bacteria, which can positively affect inflammatory processes and metabolic health.

Changes in the Microbiome on the Keto Diet

The reasons for the impact of the ketogenic diet (KD) are related to a significant reduction in carbohydrates and dietary fibers in the diet, which decreases the number of carbohydrate-feeding bacteria and alters the balance of the microbiota. However, studies from 2025 show that on the keto diet, there is a significant increase in representatives of the genera Akkermansia and Parabacteroides, microorganisms associated with reduced inflammation and improved gut functions.

Anti-inflammatory Effect

During ketosis, the body produces beta-hydroxybutyrate (BHB) — a ketone body that, according to research, affects the activity of genes that enhance mitochondrial function and suppress inflammatory processes. This supports overall metabolic health and reduces the risk of chronic diseases associated with inflammation.

Antiepileptic Properties through the Microbiome

The study paid special attention to the antiepileptic effect of KD. Experiments on mouse models and clinical observations show that changes in the microbiome, particularly the increase of Akkermansia and Parabacteroides, enhance resistance to seizures. This is linked to changes in genes regulating neuronal development and stress responses.

Recommendations and Warnings

At the same time, classical studies remind us of the need for a cautious approach to the ketogenic diet due to the potential reduction in the diversity of beneficial fiber-feeding microbiota, which can lead to imbalance and the risk of inflammatory bowel diseases. It is recommended to monitor fiber intake and consult a physician before implementing a keto diet.

Thus, new scientific data from 2025 confirms that the ketogenic diet can not only reduce weight but also positively alter the microbiome, reducing inflammation and supporting neuroimmune health, opening new prospects for the application of the keto diet in the therapy and prevention of chronic diseases.