TOP-5 Studies on Biohacking and Longevity from 09.11.2026 to 09.18.2026
Subcellular signaling networks of sirtuins: key regulators of cardiovascular homeostasis and remodeling; Similarities and differences between extravascular and subcutaneous implantable cardioverter-defibrillators: clinical selection and implantation (Part 1); Chronic pain in middle age; How to live for centuries: common features of organisms with exceptional longevity; Protein consumption throughout life: optimizing health, function, and longevity.
5. Subcellular signaling networks of sirtuins: key regulators of cardiovascular homeostasis and remodeling.
About the work.
The aim of the study is to systematically investigate the roles of sirtuins in maintaining cardiovascular homeostasis. The focus of the analysis is on the molecular mechanisms regulating inflammation and vascular remodeling.
Results.
Sirtuins play a key role in protecting against cardiovascular remodeling, atherosclerosis, and heart failure by modulating macrophage polarization and reducing vascular inflammation through the NF-κB signaling pathway. Sirtuin-based strategies for treating acute and chronic cardiovascular diseases are proposed.
4. Similarities and differences between extravascular and subcutaneous implantable cardioverter-defibrillators: clinical selection and implantation (Part 1).
About the work.
A review of two platforms of implantable cardioverter-defibrillators without transvenous access: subcutaneous (S-ICD) and extravascular (EV-ICD). Aspects of patient selection and implantation are discussed.
Results.
Long-term trial data confirm the reliability of S-ICD defibrillation without invasive leads, with lower rates of lead failure, infections, and pneumothorax compared to transvenous systems. EV-ICD demonstrated effective defibrillation and anti-tachycardia pacing in about 77% of cases.
3. Chronic pain in middle age.
About the work.
The study focuses on chronic pain in women during menopause, including the impact of reproductive changes and biopsychosocial factors on pain manifestation. Common chronic pain syndromes and the need for an integrated approach to their treatment are discussed.
Results.
Approximately half of middle-aged women experience chronic pain, often with overlapping syndromes such as fibromyalgia and migraine. Chronic pain is a significant health issue, often underestimated and underdiagnosed.
2. How to live for centuries: common features of organisms with exceptional longevity.
About the work.
The study aims to understand the differences in lifespan among organisms, especially among species living over 250 years. Mechanisms regulating both intra- and inter-species variation in lifespan are examined.
Results.
Similarities in mechanisms related to DNA maintenance, stem cells, and stress management have been identified, which are characteristic of both intra- and inter-species variation in lifespan.