TOP-5 studies on nutrients and orthomolecular medicine from 01.10.2026 - 08.10.2026
Modulation of stress and sleep using a multi-component dietary supplement: a randomized, double-blind, placebo-controlled study; The gut-kidney-brain axis in chronic kidney disease: mechanisms and nutritional interventions for the protection of cognitive functions; Effects of calcitriol (1,25(OH)₂D₃) on endothelial-derived factors related to the vulnerability of atherosclerotic plaques; Interaction of vitamin D3 and the Nrf2 signaling pathway: mechanistic aspects and therapeutic potentials; Interaction of vitamin D and the growth hormone/insulin-like growth factor 1 axis in children: a systematic review and meta-analysis.
5. Modulation of stress and sleep using a multi-component dietary supplement: a randomized, double-blind, placebo-controlled study.
About the study.
The study aimed to assess the impact of morning adaptogens and evening sleep supplements on stress, mood, and sleep quality in healthy physically active adults. The effects of various combinations of supplements were compared over four weeks.
Results.
The group receiving morning adaptogens showed a reduction in weekly stress perception. Morning use of adaptogens was associated with improvements in subjective stress, sleep quality, and positive mood compared to placebo.
4. The gut-kidney-brain axis in chronic kidney disease: mechanisms and nutritional interventions for the protection of cognitive function.
About the study.
This review explores the link between chronic kidney disease (CKD) and cognitive impairments through the gut-kidney-brain axis, emphasizing the role of nutrition as a potential intervention direction.
Results.
CKD is associated with a decrease in short-chain fatty acid-producing bacteria and an increase in proteolytic organisms, leading to elevated levels of indoxyl sulfate and p-cresyl sulfate. Metabolic disturbances in IS and PCS are linked to a disruption of the blood-brain barrier, activation of microglia, and deterioration of attention, executive function, and memory in humans.
3. Effects of calcitriol (1,25(OH)₂D₃) on endothelial-derived factors related to the vulnerability of atherosclerotic plaques.
About the study.
The study aimed to evaluate the effect of calcitriol on the expression of factors associated with the vulnerability of atherosclerotic plaques in human aortic endothelial cells. Levels of various markers were compared under baseline conditions and upon activation of cells with TNF-α.
Results.
Calcitriol had no significant effect on the baseline expression of MMP-2, MMP-9, TIMP-1, or TIMP-2, but reduced the level of mRNA MCP-1. In TNF-α activated cells, calcitriol decreased the expression of MMP-9 and MCP-1, restored TIMP-2 levels, increased the ratio of pro-/active MMP-2, and enhanced mRNA expression of OPG, although this was not accompanied by an increase in OPG protein levels.
2. Interaction of vitamin D3 and the Nrf2 signaling pathway: mechanistic aspects and therapeutic potentials.
About the study.
This study examines the interaction between vitamin D3 and the Nrf2 signaling pathway, as well as their potential in the therapy of various diseases. The focus is on the mechanisms through which vitamin D3 may influence Nrf2-regulated protective responses.
Results.
The available abstract does not provide sufficient detail on the results.