TOP-5 studies on nutrients and orthomolecular medicine from 29.10.2026 - 05.11.2026
The impact of vitamin D3 supplementation on glycemic parameters and insulin sensitivity in prediabetic adults: a prospective controlled interventional study; Healthy Eating Index and bone health in obesity; Gene-diet interactions and nutrient-responsive pathways in breast cancer: current data and implications for clinical nutrition; Hormonal remodeling and molecular mechanisms in postmenopausal osteoporosis: pathogenesis and therapeutic implications (Review); Expanding the non-calcemic roles of vitamin D in therapy and their mechanisms.
5. The impact of vitamin D3 supplementation on glycemic parameters and insulin sensitivity in prediabetic adults: a prospective controlled interventional study.
About the work.
The study aims to evaluate the impact of vitamin D3 supplementation on glycemic parameters and insulin sensitivity in adults with prediabetes. In a controlled interventional study, changes in glucose and insulin levels were compared between the supplementation group and the control group.
Results.
The vitamin D group showed a significant reduction in FBG, PPBG, HOMA-IR, and HbA1c levels, as well as an increase in 25(OH)D levels. Glycemic normalization occurred in 40% of participants in the vitamin D group compared to 11% in the control group.
4. Healthy Eating Index and bone health in obesity.
About the work.
The review examines the impact of diet quality, assessed using the Healthy Eating Index (HEI), on bone health in overweight and obese individuals. Recent studies showing a link between high HEI and bone parameters are discussed.
Results.
Recent studies show a positive association of high HEI with bone parameters in overweight and obese individuals. Specifically, higher trabecular bone score (TBS), higher bone mineral density (BMD) in the lumbar and hip neck regions, lower risk of osteoporosis, and higher serum 25-hydroxyvitamin D levels are reported in populations with higher HEI.
3. Gene-diet interactions and nutrient-responsive pathways in breast cancer: current data and implications for clinical nutrition.
About the work.
The review aims to synthesize data on interactions between genetic predisposition and dietary factors in the context of breast cancer. Three main areas are considered: associations of genotype and diet, modification of molecular pathways responsive to nutrients, and the influence of nutrition on tumor molecular phenotypes.
Results.
Within the domain of germline nutrigenetics, the most compelling data relate to the BRCA1/2, COMT, CYP17A1, GST family, MTHFR genes, and some variants of FTO, although formal interaction tests and their reproducibility have been inconsistent. Data on TP53 and FOXO3 were mostly mechanistic or preclinical and interpreted as modulation of nutrient-responsive pathways rather than established gene-diet interactions.
2. Hormonal remodeling and molecular mechanisms in postmenopausal osteoporosis: pathogenesis and therapeutic implications (Review).
About the work.
The molecular mechanisms and hormonal changes associated with postmenopausal osteoporosis, as well as therapeutic approaches to its treatment, are discussed. Interactions of various hormones and their impact on bone tissue status in postmenopausal women are examined.