TOP-5 studies on nutrients and orthomolecular medicine from 22.10.2026 - 29.10.2026
Additive effects of active form of vitamin D3 or vitamin E on therapeutic home exercises for lower extremities in knee osteoarthritis: a pilot prospective randomized controlled study; Addition of vitamin D and improvement of insomnia symptoms in Malaysian women with vitamin D deficiency: protocol for a randomized controlled trial; Vitamins and supplements in dry eye syndrome: current data and clinical implications according to the TFOS lifestyle report: nutrition; Methylmalonic acid in skeletal aging and osteoporosis: the link between vitamin B12 metabolism and mitochondrial dysfunction; Common questions and misconceptions about diets: what the scientific data really shows.
5. Additive effects of active form of vitamin D3 or vitamin E on therapeutic home exercises for lower extremities in knee osteoarthritis: a pilot prospective randomized controlled study.
About the study.
The study aims to evaluate the effect of adding active vitamin D3 or vitamin E to home exercises for lower extremities in women with knee osteoarthritis. The results of the groups receiving only exercises were compared to the groups with added vitamins.
Results.
All groups showed significant improvement on the JKOM scale, quadriceps strength, and in the 10-meter test. Improvement in grip strength was significant only in the active vitamin D group. No significant differences were found between groups for the other measures.
4. Addition of vitamin D and improvement of insomnia symptoms in Malaysian women with vitamin D deficiency: protocol for a randomized controlled trial.
About the study.
The study aims to evaluate the effectiveness of weekly vitamin D₃ supplementation in improving insomnia symptoms and related measures in Malaysian women with vitamin D deficiency.
Results.
The available abstract does not describe the results in sufficient detail.
3. Vitamins and supplements in dry eye syndrome: current data and clinical implications according to the TFOS lifestyle report: nutrition.
About the study.
The study focuses on the role of vitamins and polyunsaturated fatty acids in maintaining the health of the eye surface in dry eye. It discusses biological mechanisms and clinical data supporting their impact on epithelial condition and inflammatory processes.
Results.
Although supplements may be beneficial for certain patients, clinical data remain heterogeneous.
2. Methylmalonic acid in skeletal aging and osteoporosis: the link between vitamin B12 metabolism and mitochondrial dysfunction.
About the study.
The review links vitamin B12 metabolism and methylmalonic acid (MMA) levels to disturbances in bone homeostasis, exploring the impact of these factors on osteoporosis and skeletal aging.
Results.
Elevated MMA levels are associated with low bone mineral density, increased risk of osteoporosis, and reduced knee extensor strength. Vitamin B12 metabolism disruption is linked to changes in bone turnover, while MMA affects mitochondrial respiration, energy metabolism, and extracellular matrix quality.