TOP-5 studies on disease treatment from 18.10.2026 to 25.10.2026
Metabolic ketosis weakens NLRP3 inflammasome activation and is associated with improved liver steatosis and stiffness in MASLD: a pilot randomized controlled trial; Potential links between PCOS/PMOS and Alzheimer's disease and related dementias; Approach to patients after gestational diabetes: what next?; DHA as a systemic regulator of neuroinflammation: a narrative review integrating membrane organization, immunometabolism, and resolution of inflammation; Brain-derived neurotrophic factor in diabetes: a promising target for cognitive function recovery.
5. Metabolic ketosis weakens NLRP3 inflammasome activation and is associated with improved hepatosteatosis and liver stiffness in MASLD: a pilot randomized controlled trial.
About the study.
The study aimed to evaluate the impact of a ketogenic diet on inflammatory processes and liver condition in patients with metabolic dysfunction related to fatty liver disease (MASLD). The results of using a medium-chain fatty acid-enriched formula were compared to a standard low-carbohydrate diet.
Results.
The intervention with the C8-enriched formula led to increased levels of β-hydroxybutyrate, improved metabolic parameters, including reduced serum glucose, HOMA-IR, body fat percentage, and BMI. Changes in inflammation markers were also recorded, including the expression of caspase-1 mRNA and NLRP3, as well as improvements in hepatosteatosis and liver stiffness.
4. Potential links between polycystic ovary syndrome/postmenopausal osteoporosis and Alzheimer's disease and related dementias.
About the study.
The study aimed to identify potential links between polycystic ovary syndrome/polyendocrine metabolic syndrome and Alzheimer's disease. Mechanisms that may connect these conditions with cognitive impairments and dementia risk were evaluated.
Results.
Evidence supports the existence of several potential mechanistic pathways linking PCOS/PMOS with biology related to Alzheimer's disease, including insulin resistance, chronic inflammation, and hormone dysfunction. Patients with PCOS/PMOS exhibit mild but reproducible impairments in executive function and memory, as well as structural and functional changes in the brain.
3. Approach to patients after gestational diabetes: what next?
About the study.
The study is dedicated to the consequences of gestational diabetes and the need for ongoing monitoring of women after its occurrence. The risks of developing type 2 diabetes and cardiovascular diseases in these women are discussed.
Results.
Women with a history of gestational diabetes have an increased risk of developing type 2 diabetes and cardiovascular diseases. Long-term monitoring and counseling are necessary to reduce the risk of progression to diabetes and cardiovascular diseases.