TOP-5 Studies on Biohacking and Longevity from June 19, 2026 - June 26, 2026
REPROGRAMMING: Promoting resilience through geroprotectors: Assessment of biological effect: Justification and protocol for testing biological effect; The impact of metformin on healthspan-related outcomes and age-related disease morbidity in individuals with type 2 diabetes; Time travel: The evolution of treatment for individuals with Parkinson's disease; Gene therapy for aging and longevity; Circadian rhythms and non-coding RNAs: mechanistic aspects, clinical significance, and future opportunities for personalized medicine.
5. REPROGRAMMING: Promoting resilience through geroprotectors: Assessment of biological effect: Justification and protocol for testing biological effect.
About the study.
The study aims to assess the impact of geroprotectors on biological mechanisms related to low resilience to physiological stressors in healthy older adults. The trial compared three geroprotectors: Metformin, Fisetin, and Spermidine.
Results.
The available abstract does not describe the results in sufficient detail.
4. The impact of metformin on healthspan-related outcomes and age-related disease morbidity in individuals with type 2 diabetes: a systematic review.
About the study.
The aim of the research was to determine the impact of metformin on healthspan and morbidity in individuals with type 2 diabetes. The systematic review analyzed observational studies regarding the effects of metformin on various age-related diseases.
Results.
Use of metformin in individuals with type 2 diabetes is associated with a reduced risk of all-cause mortality, cardiovascular disease morbidity, and dementia. Metformin was associated with a decreased risk of prostate cancer; however, effects varied by cancer type and remain uncertain.
3. Time travel: the evolution of treatment for individuals with Parkinson's disease.
About the study.
The research aims to create an evidence base for rehabilitating patients with Parkinson's disease and translating this data into improved real-world outcomes. It examines the historical development of the evidence base, the gap between potential and performance, and various intervention approaches.
Results.
The available abstract does not describe the results in sufficient detail.
2. Gene therapy for aging and longevity.
About the study.
Achievements in gene therapy for combating aging and age-related diseases are discussed, as well as prospects for their clinical application.
Results.
Recent advancements show that gene therapies can directly target aging mechanisms. Gene-based therapies have improved conditions in several age-related pathologies, such as childhood Parkinsonism. Despite existing challenges, longevity gene therapy offers a promising pathway to reprogram aging and slow age-related decline.