TOP-5 studies on nutrients and orthomolecular medicine from 06.18.2026 - 06.25.2026
Do probiotics modulate food intake? Pilot data from a randomized controlled sub-study of the ProBioHRV clinical trial in patients with depression and healthy controls; The effect of perilla oil on platelet and inflammatory responses in healthy smokers: a randomized, double-blind, placebo-controlled parallel study; Dietary intervention targeting obesity in mothers: intergenerational effects, mechanisms, and translational aspects; Vitamin D in Alzheimer's disease: neuroinflammatory, metabolic, and clinical consequences; A systematic review of clinical and laboratory effects of vitamin D deficiency in children with sickle cell disease.
5. Do probiotics modulate food intake? Pilot data from a randomized controlled sub-study of the ProBioHRV clinical trial in patients with depression and healthy controls.
About the work.
The study aimed to evaluate the effect of probiotics on food intake in patients with major depression and healthy controls. A randomized controlled trial analyzed changes in dietary intake after three months of probiotic supplementation.
Results.
Changes in dietary indicators were generally insignificant, with only a few reaching statistical significance. In healthy participants, probiotics were associated with increased vitamin D intake after one week, while in depressed patients, a similar increase was observed after three months (at trend level, p = .058).
4. The effect of perilla oil on platelet and inflammatory responses in healthy smokers: a randomized, double-blind, placebo-controlled parallel study.
About the work.
The study evaluated the effect of perilla oil supplementation on blood coagulation and inflammatory responses in healthy smokers over 8 weeks. Results were compared between the oil group and the control group.
Results.
Perilla oil intake significantly increased ADP closure time, reduced mRNA expression of tumor necrosis factor-α and T-box transcription factor 21, and increased levels of alpha-linolenic acid and eicosapentaenoic acid in plasma.
3. Dietary interventions targeting maternal obesity: intergenerational effects, mechanisms, and translational aspects.
About the work.
The review focuses on the impact of dietary interventions on the metabolism of mothers with obesity and the health of their offspring. Various nutrients and their mechanisms of action on maternal and child health are discussed.
Results.
Preclinical studies show that interventions improve maternal metabolism, modulate placental function, regulate gut microbiota, alter breast milk composition, and affect epigenetic programming. Evidence for folic acid and vitamin D is relatively strong, while data on dietary fibers are just beginning to emerge.
2. Vitamin D in Alzheimer's disease: neuroinflammatory, metabolic, and clinical consequences.
About the work.
The review addresses the role of vitamin D in modifying cognitive function and its relationship with the pathophysiology of Alzheimer's disease. Mechanisms by which vitamin D influences various pathogenic pathways of the disease are discussed.
Results.
Vitamin D may act as a neuroprotective factor in the aging brain by modulating amyloid metabolism, microglial activation, inflammatory signals, oxidative balance, mitochondrial function, and synaptic integrity, as well as regulating insulin resistance.