TOP-5 studies on nutrients and orthomolecular medicine from 11.06.2026 - 18.06.2026
The influence of different forms of omega-3 polyunsaturated fatty acids on dry eye syndrome arising from various causes: a meta-analysis and systematic review; Contrasting dietary patterns alter gut microbiota function and shape multi-omic signatures associated with cardiometabolic markers; The nutrigenomic-epigenetic axis in cancer: from dietary bioactives to precision oncology; Correlation between serum 25-hydroxyvitamin D levels and heart structure and function in children and adolescents with obesity combined with metabolic syndrome; Genetic polymorphisms of vitamin D, obesity, and hormonal response to genotype-based supplementation and diet intervention.
5. The influence of different forms of omega-3 polyunsaturated fatty acids on dry eye syndrome arising from various causes: a meta-analysis and systematic review.
About the work.
The aim of the study was to compare the therapeutic effects of omega-3 polyunsaturated fatty acid supplements in various forms for dry eye syndrome considering different etiologies. The study analyzed the results of 27 randomized controlled trials.
Results.
Systemic omega-3 supplements improved all assessed outcomes in the overall analysis; however, the effects depended on the formulation and etiology. Significant improvements were found in dry eye associated with the use of video displays and contact lenses, while in cases related to meibomian gland dysfunction or undefined etiology, no significant advantages were observed.
4. Contrasting dietary patterns alter gut microbiota function and shape multi-omic signatures associated with cardiometabolic markers.
About the work.
The study aimed to assess the impact of different dietary patterns on gut microbiota functions and metabolic markers in Australian adults. The effects of the Healthy Australian Diet and the Typical Australian Diet were compared.
Results.
The HAD was associated with decreased taxonomic and functional alpha diversity compared to baseline, while the TAD did not cause changes. 105 functional pathways differed between diets, of which 99 increased after HAD, mainly related to amino acid and nucleotide biosynthesis, as well as vitamin/cofactor metabolism.
3. The nutrigenomic-epigenetic axis in cancer: from dietary bioactives to precision oncology.
About the work.
The review focuses on the influence of dietary components on epigenetic mechanisms related to cancer, emphasizing bioactive substances. It discusses the mechanisms through which nutrition can exert preventive and therapeutic effects on cancer.
Results.
Compounds such as epigallocatechin-3-gallate, resveratrol, quercetin, genistein, and sulforaphane inhibit DNA methyltransferases, modulate histone acetylation and methylation, reprogram microRNA networks, and promote transcriptional states that suppress tumors; dietary patterns rich in cruciferous vegetables, green tea, grapes, whole grains, and fermentable fibers correlate.