TOP-5 Studies on Biohacking and Longevity from 12.06.2026 - 19.06.2026
REPROGRAMMING: Promoting resilience through geroprotectors: Assessment of biological effect: Justification and protocol for testing biological effect; The impact of metformin on healthspan outcomes and age-related disease morbidity in individuals with type 2 diabetes; Time travel: The evolution of treatment for people with Parkinson's disease; Gene therapy for aging and longevity; Circadian rhythms and non-coding RNAs: mechanistic aspects, clinical significance, and future opportunities for personalized medicine.
5. REPROGRAMMING: Promoting resilience through geroprotectors: Assessment of biological effect: Justification and protocol for testing biological effect.
About the work.
The study aims to assess the impact of geroprotectors on biological mechanisms related to low resilience to physiological stressors in healthy elderly individuals. Three geroprotectors were compared in the trial: Metformin, Fisetin, and Spermidine.
Results.
The available abstract does not describe the results in sufficient detail.
4. The impact of metformin on healthspan outcomes and age-related disease morbidity in individuals with type 2 diabetes: a systematic review.
About the work.
The aim of the study was to determine the impact of metformin on healthspan and morbidity in individuals with type 2 diabetes. The systematic review analyzed observational studies regarding the effects of metformin on various age-related diseases.
Results.
Use of metformin in individuals with type 2 diabetes is associated with a reduced risk of all-cause mortality, cardiovascular disease morbidity, and dementia. Metformin was associated with a decreased risk of prostate cancer; however, effects varied by cancer type and remain uncertain.
3. Time travel: the evolution of treatment for people with Parkinson's disease.
About the work.
The study aims to create an evidence base for the rehabilitation of patients with Parkinson's disease and translate this data into improved real-world outcomes. It considers the historical development of the evidence base, the gap between potential and performance, and various intervention approaches.
Results.
The available abstract does not describe the results in sufficient detail.
2. Gene therapy for aging and longevity.
About the work.
Achievements in gene therapy for combating aging and age-related diseases are discussed, along with prospects for their clinical application.
Results.
Recent advancements show that gene therapies can directly impact aging mechanisms. Single-gene-based gene therapies have improved conditions in several age-related pathologies, such as childhood parkinsonism. Despite existing challenges, longevity gene therapy offers a promising pathway to reprogram aging and slow age-related decline.