TOP-5 Studies on Nutrients and Orthomolecular Medicine from 20.08.2026 - 27.08.2026
Why serum magnesium levels are not a reliable indicator: a narrative review of magnesium biochemistry, compartmental exchange, and endpoint selection for supplementation trials; Decoding multiple sclerosis: the link between autoimmunity and nutritional/environmental factors with mitochondrial dysfunction and therapeutic opportunities; Assessment of omega-3 fatty acid status based on dried blood spots in dogs: the concept of the Omega-3 index and its dermatological perspective - Brief communication; Mediterranean diet and bone health: mechanistic pathways and implications for osteoporosis; Omega-3 and omega-6 fatty acid consumption in the diet and breast cancer risk: a systematic review and meta-analysis of cohort studies.
5. Why serum magnesium levels do not reflect the true state: a narrative review of magnesium biochemistry, compartmental exchange, and endpoint selection for supplementation trials.
About the work.
The review addresses the issue of the mismatch between biochemical endpoints of magnesium supplementation trials and the compartments in which magnesium acts. Five clinical areas are discussed where clinical benefits are reported without comparable changes in serum magnesium levels.
Results.
There are significant discrepancies between clinical outcomes and changes in serum magnesium levels, making trial endpoints insufficiently powerful. Published data show that the biological variation of serum magnesium is approximately 12%, while the critical difference for magnesium in erythrocytes is about 22%, with changes observed during oral supplementation being comparable or less.
4. Decoding multiple sclerosis: the link between autoimmunity and nutritional/environmental factors with mitochondrial dysfunction and therapeutic opportunities.
About the work.
The aim of the study is to explore the relationship between autoimmune processes, nutritional and environmental factors with mitochondrial dysfunction in multiple sclerosis. New therapeutic strategies aimed at restoring mitochondrial homeostasis are discussed.
Results.
Mitochondrial dysfunction is a key factor in the pathogenesis of multiple sclerosis, affecting axonal degeneration, chronic inflammation, and demyelination processes. Modulation of autophagy may represent an important pathophysiological pathway for therapy.
3. Assessment of omega-3 fatty acid status based on dried blood spots in dogs: the concept of the Omega-3 index and its dermatological perspective - Brief communication.
About the work.
The study aims to assess the status of omega-3 fatty acids in dogs using the Omega-3 Index concept. Levels of omega-3 fatty acids in erythrocytes and their association with chronic diseases were compared.
Results.
Healthy dogs exhibit low Omega-3 Index levels, and supplementation with omega-3 fatty acids from marine sources leads to increased concentrations in plasma and erythrocytes. Dogs with chronic diseases show reduced omega-3 status, and supplementation results in measurable biochemical changes, including decreased triglycerides and total cholesterol.
2. Mediterranean diet and bone health: mechanistic pathways and implications for osteoporosis.
About the work.
The review aims to analyze the relationship between the Mediterranean diet and the risk of osteoporosis, exploring biological mechanisms and epidemiological data. Dietary components that may influence bone health are discussed.