TOP-5 studies on disease treatment from 06.09.2026 - 13.09.2026
The role of the gut microbiome in the relationship between the Mediterranean diet and the risk of cardiovascular diseases; Signals of insulin-like growth factor receptor in physiology and pathology; Metabolic dysfunction associated with obesity and triple-negative breast cancer: epidemiological signals, mechanistic pathways, and prevention opportunities; Systematic review of a community-based assessment tool in Indian settings; The dual nature of 7-dehydrocholesterol: implications for ferroptosis, oxidative stress, and disease therapy.
5. The role of the gut microbiome in the relationship between the Mediterranean diet and the risk of cardiovascular diseases.
About the work.
The review links the Mediterranean diet, gut microbiome, and the risk of cardiovascular diseases, emphasizing functional pathways and the integration of multi-omic data.
Results.
The Mediterranean diet is associated with the enrichment of taxa that promote fiber breakdown and short-chain fatty acid production, as well as more favorable profiles of bile acids, phenols, lipids, and inflammatory markers. The microbiome may partially modify the effects of the Mediterranean diet on fat metabolism, insulin resistance, and cardiometabolic risk.
4. Signaling of insulin-like growth factor receptors in physiology and pathology.
About the work.
The review discusses the insulin-like growth factor (IGF) signaling pathway and its role in physiology and pathology. It examines IGF interactions with other signaling pathways and its impact on various diseases.
Results.
The available abstract does not describe the results in sufficient detail.
3. Metabolic dysfunction associated with obesity and triple-negative breast cancer: epidemiological signals, mechanistic pathways, and prevention opportunities.
About the work.
The connection between obesity-related metabolic dysfunction and triple-negative breast cancer (TNBC) in premenopausal women is discussed. Epidemiological and mechanistic data, as well as prevention opportunities, are considered.
Results.
Observational studies show moderate but reproducible associations between obesity and TNBC, particularly in certain high-risk metabolic populations. Mechanistic studies suggest that inflammation of adipose tissue and adipokine imbalance may contribute to inflammatory signals and aggressive characteristics associated with TNBC.
2. Systematic review of a community-based assessment tool in Indian settings.
About the work.
The study aimed to evaluate the effectiveness of the CBAC tool for identifying individuals at high risk of non-communicable diseases in India. Eleven studies meeting the inclusion criteria were analyzed in the systematic review.
Results.
The prevalence of individuals classified as high-risk for non-communicable diseases ranged from 14.4% to 68.6%. Higher CBAC scores were associated with age, tobacco and alcohol use, physical inactivity, increased waist circumference, family history of NCDs, and low education levels. The diagnostic accuracy of CBAC was moderate, with the area under the curve ranging from 0.62 to 0.