TOP-5 Studies on Keto, Low-Carbohydrate Diets, and Intermittent Fasting from 21.09.2026 - 28.09.2026
The ketogenic diet as a strategy for immunometabolic sensitization at the systemic level in cancer therapy: integration of metabolism, immune system reprogramming, microbiome dynamics, and epigenetic regulation; Beyond the classical: a systematic review of alternative and adjunctive treatments for GLUT1 deficiency syndrome; Harmful and beneficial diets regulate acute pancreatitis; Neuroenergetic flexibility in the aging brain: cellular mechanisms and dietary-induced metabolic switching; The impact of anti-aging diets and physical activity on age-related musculoskeletal diseases.
5. Harmful and beneficial diets regulate acute pancreatitis through similar gut microbiota pathways.
About the work.
The influence of various diets on gut microbiota and their connection to acute pancreatitis is examined. Harmful and beneficial diets are compared in the context of their impact on the pathogenesis of the disease.
Results.
Harmful diets exacerbate acute pancreatitis by causing dysbiosis, reducing short-chain fatty acid levels, impairing gut barrier function, and promoting inflammatory responses; beneficial diets slow disease progression by enriching probiotics, increasing short-chain fatty acid synthesis, and enhancing barrier integrity.
4. Neuroenergetic flexibility in the aging brain: cellular mechanisms and dietary-induced metabolic switching.
About the work.
This review focuses on the study of neuroenergetic flexibility in the aging brain, the mechanisms that define it, and the impact of diet on metabolic switching. Changes in metabolism with age and the potential to improve this flexibility through dietary interventions are discussed.
Results.
Evidence suggests that ketogenic diets, intermittent fasting, and calorie restriction can alter substrate availability and utilization, activating mitochondrial, cellular stress responses, and nutrient sensing pathways. However, changes in the use of alternative substrates are more consistently demonstrated than coordinated improvements in mitochondrial, vascular, cellular, and functional outcomes.
3. The ketogenic diet as a strategy for systemic sensitization in immunometabolic cancer therapy: integration of metabolism, immune system reprogramming, microbiome dynamics, and epigenetic regulation.
About the work.
This study aims to evaluate the ketogenic diet as a strategy for immunometabolic sensitization in cancer therapy. Interconnected biological mechanisms that may enhance responses to current cancer treatments are examined.
Results.
The available abstract describes the results insufficiently in detail.
2. Beyond the classical ketogenic diet: a systematic review of alternative and adjunctive therapies for GLUT1 deficiency syndrome.
About the work.
The aim of the study was to systematically summarize clinical data on non-ketogenic and additional therapeutic strategies for children with glucose transporter type 1 deficiency syndrome (GLUT1-DS), particularly for patients who do not respond to the classical ketogenic diet.