TOP-5 Studies on Keto, Low-Carbohydrate Diets, and Intermittent Fasting from 10.05.2026 to 10.12.2026
The ketogenic diet induces metabolic reprogramming and alters myogenic markers in skeletal muscle in obese male mice subjected to medial meniscus destabilization; The gut microbiota-epilepsy axis: bibliometric trends, mechanistic aspects, and next-generation therapeutic opportunities targeting the microbiota; New insights into the pathogenesis of osteoporosis and a translational approach to personalized therapy; Lifestyle interventions for cardiometabolic health in women with polycystic ovary syndrome: a systematic review and network meta-analysis; Intermittent fasting as a therapeutic strategy in Alzheimer's disease: understanding the modulation of brain-derived neurotrophic factor.
5. The gut microbiota-epilepsy axis: bibliometric trends, mechanistic aspects, and next-generation therapeutic opportunities targeting the microbiota.
About the work.
The review discusses the mechanisms by which gut dysbiosis influences epilepsy, including interactions through the gut-brain axis. The study focuses on both human and animal models, emphasizing new mechanisms and therapeutic opportunities.
Results.
The available abstract does not describe the results in sufficient detail.
4. New insights into the pathogenesis of osteoporosis and a translational approach to personalized therapy.
About the work.
The study aims to understand the pathogenesis of osteoporosis as a heterogeneous syndrome with various subtypes and mechanisms. It examines differences in metabolism, fracture patterns, and therapeutic responses for different subtypes of osteoporosis.
Results.
The results are not described in sufficient detail, but the importance of differences in the consequences of weight loss and the influence of parathyroid hormone on osteogenesis is emphasized.
3. Lifestyle interventions for cardiometabolic health in women with polycystic ovary syndrome: a systematic review and network meta-analysis.
About the work.
The aim of the study was to systematically evaluate and compare various lifestyle modification methods to improve cardiometabolic outcomes in women with polycystic ovary syndrome. Five outcome areas were examined, including anthropometry, glucose and insulin regulation, lipid profile, inflammation, and blood pressure.
Results.
The ketogenic diet reduced waist circumference and body mass index, while aerobic exercise was found to be the most effective for reducing the waist-to-hip ratio. Exercises aimed at harmonizing body and mind were most effective in reducing insulin resistance.
2. The ketogenic diet induces metabolic reprogramming and alters myogenic markers in skeletal muscle in obese male mice subjected to medial meniscus destabilization.
About the work.
The study aims to assess the impact of the ketogenic diet on skeletal muscle adaptation in obese mice with knee joint injury. Changes in metabolism and myogenic markers in skeletal muscle were compared with the use of a ketogenic diet.
Results.
The ketogenic diet led to weight loss, reduced glycemia, and increased circulating β-hydroxybutyrate without decreasing the absolute mass of the gastrocnemius or impairing motor function. In skeletal muscle, there was an increase in the expression of Acat1 and myogenic markers Pax7, Myf5, and MyoD1, indicating possible changes in the state of satellite cells and pathways related to myogenesis.