TOP-5 studies on obesity, diabetes, and insulin resistance from 06.10.2026 - 13.10.2026
Effectiveness of subtype BL-99 in the treatment of functional constipation: a randomized placebo-controlled clinical trial; The impact of bariatric surgery on obesity-associated NETosis, immune modulation, and reduction of cardiovascular risk; The combined effect of multiple metals and type 2 diabetes: integration of biomonitoring data, inflammatory mechanisms, and development of a framework for future risk stratification; Indications and pathways of development of type 2 diabetes as a predictor of neurocognitive decline and dementia: clinical implications and management; Prevalence, risk factors, and adverse health consequences of osteosarcopenia in middle-aged and elderly individuals with type 2 diabetes - a review.
5. Effectiveness of subtype BL-99 in the treatment of functional constipation: a randomized placebo-controlled clinical trial.
About the study.
The aim of the study was to evaluate the effectiveness of the probiotic BL-99 in the treatment of functional constipation. The study involved 41 patients with functional constipation who were randomly assigned to receive either BL-99 or a placebo.
Results.
After 4 weeks of intervention, the BL-99 group showed a significant reduction in PAC-SYM scores compared to placebo, particularly in the areas of "abdominal discomfort" and "pain during defecation." These improvements were maintained for 2 weeks after the end of treatment.
4. The impact of bariatric surgery on obesity-associated NETosis, immune modulation, and reduction of cardiovascular risk.
About the study.
This review examines the mechanisms related to NETosis in the context of obesity and evaluates the impact of bariatric surgery on NET formation and immune modulation.
Results.
Obesity causes hyperactivation of neutrophils and excessive NET formation, leading to insulin resistance, vascular damage, and hypercoagulation. Bariatric surgery significantly reduces systemic inflammation, suppresses neutrophil activation, and decreases NET formation, resulting in improved insulin sensitivity, endothelial function, and reduced thrombosis.
3. The combined effect of multiple metals and type 2 diabetes: integration of biomonitoring data, inflammatory mechanisms, and development of a framework for future risk stratification.
About the study.
This study addresses issues related to the exposure to a mixture of heavy metals and the development of type 2 diabetes, including biomonitoring methods and inflammatory mechanisms. Current approaches to assess the joint effects of metals on glycemia are discussed.
Results.
Despite significant methodological advancements, there is currently no validated procedure that integrates exposure metrics, inflammatory biomarkers, and clinical variables for individual risk stratification.
2. Indications and mechanisms of type 2 diabetes as a predictor of neurocognitive decline and dementia: clinical implications and management.
About the study.
This study focuses on the relationship between type 2 diabetes and neurocognitive decline, as well as dementia. Common biological mechanisms that may contribute to this process are examined.
Results.
The available abstract does not provide sufficient detail on the results.