TOP-5 Studies on Obesity, Diabetes, and Insulin Resistance from 27.10.2026 - 03.11.2026
Comparison of clinical, metabolic, and hormonal profiles in women with polycystic ovary syndrome with obesity and normal weight: systematic review and meta-analysis; Metabolic, hormonal, and reproductive effects of GLP-1 receptor agonists in women with hyperandrogenism and insulin resistance; Intervention study for weight reduction to find an effective obesity management strategy and target weight loss volume to reduce diseases (SLIM-TARGET): randomized controlled trial; Vitamin D: physiology, pharmacology, and clinical data on the need for supplementation - narrative review; Tissue-specific regulation of glucose and lipid metabolism by microRNA-29a in insulin resistance and type 2 diabetes.
5. Comparison of clinical, metabolic, and hormonal profiles in women with polycystic ovary syndrome with obesity and normal weight: systematic review and meta-analysis.
About the study.
The aim of the study was to compare clinical, metabolic, and hormonal profiles in women with polycystic ovary syndrome (PCOS) depending on the presence of obesity. Data from 42 studies were analyzed in the systematic review and meta-analysis.
Results.
Higher rates of menstrual disorders, hirsutism, acne, acanthosis, and biochemical hyperandrogenism were discussed in women with obesity compared to lean women. Obesity is associated with a less favorable cardiometabolic profile, including higher levels of HOMA-IR, glucose, and risks of prediabetes, diabetes, and metabolic syndrome.
4. Metabolic, hormonal, and reproductive effects of GLP-1 receptor agonists in women with hyperandrogenism and insulin resistance: systematic review.
About the study.
The aim of the study was to systematically evaluate the effects of GLP-1 receptor agonists on metabolic, hormonal, and reproductive outcomes in women with hyperandrogenic insulin resistance. The subjects of the study were women with polycystic ovary syndrome and HAIR-AN syndrome.
Results.
Metabolic responses were more consistent and pronounced than endocrine outcomes. Reproductive outcomes, such as menstrual cycle regularity, were reported with variable frequency and showed inconsistent improvement, limiting the ability to draw firm conclusions about fertility benefits. Data on severe phenotypes remain limited but suggest clinical benefits.
3. Intervention study for weight reduction to find an effective obesity management strategy and target weight loss volume to reduce diseases (SLIM-TARGET): randomized controlled trial.
About the study.
The study aimed to determine target weight loss goals for improving obesity-related diseases in overweight individuals. Participants were assigned to standard and intensive groups with different weight loss goals.
Results.
As a result, remission of diseases was achieved in 16.9% of participants in the intensive group compared to 6.2% in the standard group. Reduction of visceral fat was greater in the intensive group (-20.46 cm vs -8.9 cm). Intensive treatment significantly improved blood pressure control and increased treatment motivation by 10.9%.