TOP-5 studies on nutrients and orthomolecular medicine from 28.05.2026 - 04.06.2026
Epigenetic and genetic aspects for individualized therapeutic strategies in multiple sclerosis; The impact of maternal vitamin D levels during pregnancy on the risk of diagnosis and symptoms of autism spectrum disorder and attention deficit hyperactivity disorder in offspring: a systematic review and meta-analysis assessing dose-dependence; Bone health in gender diverse individuals: current issues and future directions; The effect of vitamin D supplementation and its status on seizure frequency and quality of life in drug-resistant epilepsy: a systematic review and meta-analysis; The effect of multiple micronutrient supplementation on cognitive functions in children: a systematic review and meta-analysis of randomized controlled trials.
5. Epigenetic and genetic aspects for individualized therapeutic strategies in multiple sclerosis.
About the work.
The study aims to identify genetic and epigenetic factors influencing multiple sclerosis to develop personalized therapeutic strategies. Genetic loci and their interaction with the environment were analyzed.
Results.
HLA-DRB1*15:01 is a key genetic risk factor, and epigenetic changes such as DNA methylation affect disease progression. New biomarkers like CHI3L1 and miR-155 show potential for diagnosis and prognosis.
4. The impact of maternal vitamin D levels during pregnancy on the risk of diagnosis and symptoms of autism spectrum disorder and attention deficit hyperactivity disorder in offspring: a systematic review and meta-analysis of dose-dependence.
About the work.
The study assessed the relationship between maternal vitamin D levels during pregnancy and the risk of diagnosis and symptoms of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in offspring. The meta-analysis included comparisons of different exposure categories.
Results.
Comparison of high and low maternal vitamin D levels showed an inverse association with the risk of ASD (RR = 0.91; 95% CI 0.87-0.96) and ADHD (RR = 0.90; 95% CI 0.82-0.99). The risk of ASD decreased linearly by 9% with each 10 nmol/L increase in serum vitamin D levels.
3. Bone health in gender diverse individuals: current issues and future directions.
About the work.
The review addresses bone health issues in transgender and gender diverse individuals, focusing on the impact of hormone therapy on bone mineral density and fracture risk. Data on bone health, screening, and the effects of gonadotropin-releasing hormone agonists in adolescence are discussed.
Results.
Several cohorts report low bone mineral density before starting hormone therapy, especially in individuals assigned male at birth. Appropriately managed hormone therapy typically maintains or slightly improves bone mineral density, particularly in individuals assigned female at birth on testosterone. Data on fractures are limited but encouraging.
2. The effect of vitamin D supplementation and its status on seizure frequency and quality of life in drug-resistant epilepsy: a systematic review and meta-analysis.
About the work.
The study aimed to systematically evaluate the impact of vitamin D supplementation and vitamin D levels on seizure frequency and quality of life in patients with drug-resistant epilepsy. Data from eleven studies were analyzed.