TOP-5 Studies on Disease Treatment from June 21, 2026 to June 28, 2026
Individualized video-based lifestyle intervention for adults with overweight or obesity in Phnom Penh, Cambodia: a pilot cluster randomized controlled trial; Identification of microRNAs as biomarkers of idiopathic intracranial hypertension: a pilot study; Phenolic-rich extruded sorghum-based beverage BRS 305 improves fecal and blood metabolites, oxidative balance, and cardiometabolic markers in overweight adults: a single-blinded, randomized, placebo-controlled study; Nrf2 in obesity: mechanisms, models, and bioactive modulators; Cardiovascular-renal-metabolic syndrome through the lens of intestinal uremic toxins.
5. Individualized video-based lifestyle intervention for adults with overweight or obesity in Phnom Penh, Cambodia: a pilot cluster randomized controlled trial.
About the study.
The study aimed to evaluate the effectiveness of a video intervention on physical activity and nutrition among adults aged 30-59 years in Phnom Penh, Cambodia. A total of 63 participants were included, with 31 in the intervention group and 32 in the control group.
Results.
The intervention group showed significant improvements in adherence to physical activity, adherence to healthy eating, self-efficacy in exercise and healthy eating, as well as in systolic blood pressure, body weight, body mass index, waist circumference, fasting blood glucose levels, and high-density lipoprotein cholesterol levels compared to the control group (P < .05).
4. Identification of microRNAs as biomarkers of idiopathic intracranial hypertension: a pilot study.
About the study.
The study aimed to identify microRNAs (miRNAs) in serum associated with idiopathic intracranial hypertension (IIH) and disease activity. Levels of miRNAs were compared among women with active IIH, remission, and control groups with obesity and migraine.
Results.
Five out of 40 serum miRNAs showed significantly lower expression in active IIH compared to remission. hsa-miR-16-5p demonstrated the highest diagnostic efficiency for active IIH (area under the curve 0.951). hsa-miR-16-5p and hsa-miR-7-5p were significantly lower in active IIH compared to the obesity control group, while hsa-miR-7a-5p was significantly higher in active IIH compared to migraine.
3. Phenolic-rich extruded sorghum-based beverage BRS 305 improves fecal and blood metabolites, oxidative balance, and cardiometabolic markers in overweight adults: a single-blinded, randomized, placebo-controlled study.
About the study.
The study aimed to evaluate the effects of phenolic extract from sorghum BRS305 on metabolic parameters and oxidative balance in overweight adults. The randomized controlled trial compared the effects of the sorghum beverage and a control beverage on various biochemical markers.
Results.
The sorghum beverage demonstrated a high diversity of phenolic compounds, reflected in increased concentrations of trans-caffeic acid and naringenin in the plasma of the group consuming the sorghum beverage, as well as an increase in total antioxidant capacity of the plasma. The group consuming the sorghum beverage showed decreased levels of insulin, triglycerides, HOMA-IR, and TyG index, along with increased HDL-c and decreased Castelli indices.