TOP-5 studies on obesity, diabetes, and insulin resistance from 06.23.2026 - 06.30.2026
The impact of tomatoes and tomato-based products on obesity and cardiometabolic health: a systematic review and meta-analysis; Sulforaphane reprograms the metabolomic landscape of chronic kidney disease: data from NMR metabolomics; Elecoglipron, an oral small-molecule GLP-1 receptor agonist in adults with type 2 diabetes (SOLSTICE): a multicenter, phase 2b, randomized, placebo-controlled trial; The effect of different training modalities on circulating irisin levels in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials; The impact of incretin therapies, dietary and physical interventions, and bariatric surgery on fat-free mass in overweight or obese adults: a systematic review and meta-analysis.
5. The impact of tomatoes and tomato-based products on obesity and cardiometabolic health: a systematic review and meta-analysis.
About the work.
The review aims to assess the impact of tomatoes and tomato-based products on parameters related to obesity and cardiometabolic health in overweight individuals. The study compared the results of clinical trials, epidemiological, and preclinical studies.
Results.
In clinical trials, tomato-based interventions led to a small but significant reduction in waist circumference, with no consistent effects on body weight or body mass index. Epidemiological studies consistently linked higher tomato consumption with more favorable cardiometabolic profiles, while preclinical models showed reductions in visceral fat, inflammation, and oxidative stress.
4. Sulforaphane reprograms the metabolomic landscape of chronic kidney disease: data from NMR metabolomics.
About the work.
The study aims to evaluate the impact of adding sulforaphane on the metabolomic profile of patients with chronic kidney disease (CKD) stages 3-5. A randomized controlled clinical trial compared the effects of sulforaphane and placebo.
Results.
Sulforaphane contributed to the reduction of levels of 2-hydroxyisovalerate and glycerol, associated with insulin resistance and oxidative stress, and also decreased methanol levels. Correlations were found between heme oxygenase-1 and several amino acids, as well as between NRF2 and glycerol, indicating an interaction between amino acid metabolism and antioxidant defense.
3. Elecoglipron, an oral small-molecule GLP-1 receptor agonist in adults with type 2 diabetes (SOLSTICE): a multicenter, phase 2b, randomized, placebo-controlled trial.
About the work.
The study aims to evaluate the efficacy, safety, and tolerability of elecoglipron compared to placebo in adults with type 2 diabetes. Participants from nine countries were included in the multicenter randomized clinical trial.
Results.
The available abstract does not describe the results in sufficient detail.
2. The effect of different training modalities on circulating irisin levels in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials.
About the work.
The aim of this systematic review and meta-analysis was to assess the impact of different types of physical activity on circulating irisin levels in overweight and obese individuals. Various training protocols, including aerobic and strength training, were investigated.
Results.
Physical activity was associated with a significant increase in circulating irisin levels (SMD 0.62, 95% CI 0.39-0.85).