TOP-5 Studies on Obesity, Diabetes, and Insulin Resistance from July 21, 2026 - July 28, 2026
Is acanthosis nigricans a marker of metabolic syndrome? Systematic review; The impact of time-restricted feeding on metabolism and glucose regulation markers in individuals with prediabetes or type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials; Research progress in the mechanisms of electroacupuncture in the treatment of obesity; Comorbidities between affective disorders and chronic somatic diseases, focusing on cardiometabolic diseases and their mechanistic interactions; B lymphocytes in the adipose tissue microenvironment: diverse roles in inflammation and metabolic dysfunction.
5. Is acanthosis nigricans a marker of metabolic syndrome? Systematic review.
About the work.
The aim of the study was to assess the association between acanthosis nigricans and metabolic syndrome. The systematic review included an analysis of 656 articles reporting the presence of acanthosis nigricans in the context of metabolic syndrome.
Results.
The average proportion of participants with acanthosis nigricans was 70.8%. The highest prevalence of acanthosis nigricans was observed in insulin resistance (72.6%). 65.9% of participants met more than one criterion for metabolic syndrome, with the most common combination being insulin resistance and increased body weight (25.5%). In the sub-analysis among participants with acanthosis nigricans 67.
4. The impact of time-restricted feeding on metabolism and glucose regulation markers in individuals with prediabetes or type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
About the work.
This systematic review and meta-analysis examined the impact of time-restricted feeding on metabolism and glucose regulation in individuals with prediabetes and type 2 diabetes. The results of time-restricted feeding were compared with control without time restrictions.
Results.
TRE had no overall effect on HbA, however, individuals with prediabetes showed a decrease in HbA by 0.93 mmol/mol (p=0.02), while no such effect was observed in patients with type 2 diabetes. TRE also reduced fasting glucose levels.
3. Research progress in the mechanisms of electroacupuncture in the treatment of obesity.
About the work.
The mechanisms of action of electroacupuncture in the treatment of obesity are discussed, based on research from the last decade.
Results.
Electroacupuncture influences weight reduction through several targets and pathways, including the regulation of neurons and neuropeptides, promoting the browning of white adipose tissue, modifying lipid metabolism, maintaining intestinal flora homeostasis, reducing inflammatory responses, and improving insulin resistance.
2. Comorbidities between affective disorders and chronic somatic diseases, focusing on cardiometabolic diseases, and their mechanistic interactions.
About the work.
The study is dedicated to the comorbidity of mood disorders and chronic somatic diseases, focusing on cardiometabolic diseases. The mechanisms of interaction between these conditions and their epidemiological distributions are analyzed.