TOP-5 Studies on Obesity, Diabetes, and Insulin Resistance from August 25, 2026 to September 1, 2026
School-based interventions on nutrition and physical activity and weight-related outcomes among children and adolescents in Africa: a systematic review and meta-analysis; Imbalance of toxic metals and essential micronutrients in cardiometabolic diseases: ferroptosis as a mechanistic link between environmental exposure and vascular damage; Metabolic syndrome: from mechanisms to therapeutic interventions; Progress in the molecular biological mechanisms of obesity-induced endometrial cancer; The gut microbiota and astrocytes axis: new insights into the mechanisms of comorbid major depressive disorder in type 2 diabetes.
5. School-based interventions on nutrition and physical activity and weight-related outcomes among children and adolescents in Africa: a systematic review and meta-analysis.
What the study is about.
The aim of this systematic review is to assess the impact of school-based interventions on diet and physical activity on weight outcomes among children and adolescents in Africa. The study includes 11 eligible studies, most of which were conducted in South Africa.
Results.
The studies reported modest improvements in reducing overweight and maintaining normal weight in intervention groups. However, in the meta-analysis of nine comparisons, the effect on age-adjusted body mass index was found to be insignificant.
4. Imbalance of toxic metals and essential micronutrients in cardiometabolic diseases: ferroptosis as a mechanistic link between environmental exposure and vascular damage.
What the study is about.
This review examines the impact of toxic metals on cardiometabolic diseases, including their role in disrupting the balance of essential micronutrients. It focuses on the mechanism of ferroptosis as a link between environmental exposure and vascular damage.
Results.
Toxic imbalance between metals and essential micronutrients may create a pro-ferroptotic environment that contributes to endothelial dysfunction, impaired nitric oxide synthesis, vascular stiffness, instability of atherosclerotic plaques, myocardial vulnerability to ischemia, insulin resistance, and β-cell dysfunction.
3. Metabolic syndrome: from mechanisms to therapeutic interventions.
What the study is about.
This review discusses the mechanisms of metabolic syndrome and its connection to various metabolic diseases. It addresses current treatment approaches, including both traditional and new therapeutic strategies.
Results.
The available abstract describes the results insufficiently in detail.
2. Progress in the molecular biological mechanisms of obesity-induced endometrial cancer.
What the study is about.
This study focuses on the link between obesity and endometrial cancer, emphasizing molecular mechanisms, including the role of adipokines and inflammatory signals. It examines various pathways through which obesity promotes the development of endometrial cancer.
Results.
Obesity initiates and progresses endometrial cancer through three main pathways: elevated estrogen levels, insulin resistance, and chronic inflammation. Visceral and subcutaneous obesity differentially regulate adipokine secretion and metabolic microenvironments, affecting molecular subtypes, pathological features, and response to endometrial cancer treatment.