TOP-5 studies on obesity, diabetes, and insulin resistance from June 9, 2026 - June 16, 2026
The efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycemic control through diet and physical activity (TRANSCEND-T2D-1): a double-blind, randomized, phase 3 clinical trial; The intersection of gestational diabetes and preeclampsia; Environmental diabetogens: biochemical links between microplastic exposure, endocrine disruption, and glucose metabolism dysfunction; The relationship between e-cigarette use and prediabetes, diabetes, and insulin resistance: a systematic review and meta-analysis; Mesenchymal stem cell therapy in type 2 diabetes: synergistic regeneration of β-cells, modulation of immune response, and exosome-mediated glucose homeostasis.
5. The efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycemic control through diet and physical activity (TRANSCEND-T2D-1): a double-blind, randomized, phase 3 clinical trial.
What the study is about.
The study aims to evaluate the efficacy and safety of retatrutide as monotherapy in people with type 2 diabetes inadequately controlled by diet and physical activity alone. Changes in hemoglobin A1c and body weight were assessed in a randomized double-blind placebo-controlled trial.
Results.
The available abstract does not describe the results in sufficient detail.
4. The intersection of gestational diabetes and preeclampsia: a literature review.
What the study is about.
The review discusses gestational diabetes and preeclampsia as common pregnancy complications, along with their shared risk factors and pathophysiological mechanisms. The clinical implications of their overlap and the need for integrated management strategies are discussed.
Results.
The available abstract does not describe the results in sufficient detail.
3. Environmental diabetogens: biochemical links between microplastic exposure, endocrine disruption, and carbohydrate metabolism dysfunction.
What the study is about.
The review focuses on the relationship between microplastic exposure and glucose metabolism disruption, emphasizing biochemical and molecular mechanisms. Interactions of microplastics with endocrine and metabolic pathways are examined.
Results.
Microplastic exposure may cause systemic insulin resistance, β-cell damage, systemic inflammation, and changes in gut microbiome, disrupting glucose metabolism regulation in the liver, muscles, and adipose tissue.
2. The relationship between e-cigarette use and prediabetes, diabetes, and insulin resistance: a systematic review and meta-analysis.
What the study is about.
The study aimed to examine the relationship between e-cigarette use and prediabetes, diabetes, and insulin resistance. A systematic review and meta-analysis of available epidemiological data were conducted.
Results.
For prediabetes, the combined OR for current exclusive users was 1.34, for dual users it was 1.26, and for former users it was 1.13. For diabetes, a significant increase was observed only in dual users (OR 1.23). Current exclusive users had an OR of 1.37 for insulin resistance. A prospective study did not find a significant association between exclusive e-cigarette use and type 2 diabetes.