TOP-5 studies on keto, low-carbohydrate diets, and intermittent fasting from 08.06.2026 - 15.06.2026
The impact of ketone supplements, low-carbohydrate diets, and ketogenic diets on heart failure indicators and outcomes: a systematic review and meta-analysis; The use of medium-chain triglycerides in pediatric patients with drug-resistant epilepsy without ketogenic therapy; The ketogenic diet and β-hydroxybutyrate suppress bladder cancer growth and enhance the efficacy of anti-PD-L1 immunotherapy; Fetal growth is determined by a bimodal response of fetal beta-cells and is altered by; Modern nutritional concepts for critically ill patients: a narrative review.
5. Modern approaches to nutrition for critically ill patients: a narrative review.
About the work.
Modern approaches to nutritional therapy for critically ill patients are discussed, emphasizing the individualized approach and the need to adapt nutrition according to the phases of illness. Various aspects are considered, including the impact of inflammation on metabolism and strategies for prescribing macro- and micronutrients.
Results.
Inflammation and high disease severity significantly affect the response to nutrition, with severely inflamed patients showing reduced benefits and increased risk of overeating. Personalized strategies, such as indirect calorimetry and protein dosing based on lean body mass, offer a rational approach to individualizing therapy.
4. The impact of ketone supplements, low-carbohydrate diets, and ketogenic diets on heart failure indicators and outcomes: a systematic review and meta-analysis.
About the work.
This study investigates the effects of adding ketones, low-carbohydrate, and ketogenic diets on heart function and heart failure outcomes. A systematic review and meta-analysis of existing data were conducted.
Results.
The addition of ketones increased left ventricular ejection fraction by 3.12% (95% CI 0.95% to 5.30%, p < 0.01).
3. The use of medium-chain triglycerides in children with drug-resistant epilepsy without ketogenic therapy.
About the work.
This study aims to evaluate the effectiveness of adding medium-chain triglycerides (MCT) in the treatment of children with drug-resistant epilepsy. The results of MCT application in patients before starting a ketogenic diet were examined.
Results.
A positive response to MCT treatment was observed in 66.7% of cases. The duration of treatment was positively associated with the response to therapy. 63.8% of patients continued the ketogenic diet after the MCT addition phase, of which 65.2% reported further reductions in seizure frequency.
2. The ketogenic diet and β-hydroxybutyrate suppress bladder cancer growth and enhance the efficacy of anti-PD-L1 immunotherapy.
About the work.
This study aims to evaluate the impact of the ketogenic diet and β-hydroxybutyrate on bladder cancer growth and the efficacy of immunotherapy using PD-L1 inhibitors. Tumors in the MB49 model were the subject of the study.
Results.
The ketogenic diet reduced tumor growth compared to a standard diet, increased plasma β-HB levels, and PD-L1 expression in tumors. The addition of β-HB in a standard diet also led to an anti-tumor effect and enhanced the efficacy of anti-PD-L1. β-HB increased levels of reactive oxygen species and induced apoptosis in bladder cancer cells.