TOP-5 studies on obesity, diabetes, and insulin resistance from 30.06.2026 - 07.07.2026
Skeletal muscle biomass as an underestimated fate of glucose; Comprehensive review of mechanisms of free fatty acid-induced insulin resistance and its therapeutics: molecular aspects; High-salt diet in metabolic disorders associated with macrophages: mechanisms and therapeutic implications; Consensus on behavioral strategies for adults with obesity from the Korean Society for the Study of Obesity; Interactions of polysaccharides and gut microbiota in metabolic diseases: structural selectivity, mediating mechanisms, and evidence gaps.
5. Skeletal muscle biomass as an underestimated pathway of glucose.
About the work.
The study examines the role of glucose as a building block for biomass synthesis in skeletal muscles and satellite cells. It compares the mechanisms through which glucose participates in anabolic processes in muscle cells and cancer cells.
Results.
Radio-tracer studies show that approximately 8-15% of the dry mass of cells comes from glucose. Glucose is involved in the synthesis of serine, nucleotides, lipids, and in epigenetic modifications. Resistance exercises and other interventions that promote hypertrophy improve glucose metabolism in obesity and insulin resistance.
4. Comprehensive review of mechanisms of free fatty acid-induced insulin resistance and its therapy: molecular aspects.
About the work.
The review is dedicated to the mechanisms by which free fatty acids (FFAs) cause insulin resistance and the pathogenesis of type 2 diabetes. It discusses molecular pathways affecting insulin resistance and β-cell damage.
Results.
The available abstract does not describe the results in sufficient detail.
3. High-salt diet in metabolic disorders associated with macrophages: mechanisms and therapeutic implications.
About the work.
The study focuses on the impact of a high-salt diet on chronic inflammation and insulin resistance in obesity and type 2 diabetes, with an emphasis on macrophage polarization and metabolic changes. It compares the mechanisms through which a high-salt diet affects macrophages and metabolic disorders.
Results.
A high-salt diet activates the p38/MAPK, NF-κB, and NLRP3 signaling pathways, leading to macrophage polarization into the pro-inflammatory M1 phenotype and a metabolic shift towards glycolysis. It also induces a persistent 'metabolic memory' in macrophages through epigenetic changes, including histone modifications and DNA methylation, exacerbating systemic insulin resistance.
2. Consensus on behavioral strategies for adults with obesity from the Korean Society for the Study of Obesity.
About the work.
The aim of the study was to develop culturally adapted behavioral strategies for managing obesity in Korean adults. Using a consensus approach, experts discussed and evaluated various strategies to create a practical framework for combating obesity in Korea.
Results.
The expert group formulated 10 key behavioral strategies covering five key areas: diet, physical activity, self-regulation of behavior, environmental support, and clinical assistance, as well as psychosocial and physiological factors.