TOP-5 studies on biohacking and longevity from 07.08.2026 - 14.08.2026
EXPRESS: Improving standards of physiological monitoring and reporting in preclinical stroke research; The effect of melatonin treatment before sleep on blood pressure and arterial stiffness: a three-month randomized placebo-controlled crossover study in patients with type 2 diabetes; Pulmonary cold perception; Circulating plasma follistatin follows a 24-hour rhythm in healthy young men; The human circadian rhythm protein cryptochrome-1 responds to photochemistry with conformational changes.
5. EXPRESS: Improving standards of physiological monitoring and reporting in preclinical stroke research.
About the work.
The review focuses on the importance of monitoring and reporting key physiological parameters in experimental stroke models. Aspects affecting research outcomes and the necessity of considering them in data interpretation are discussed.
Results.
The available abstract describes the results insufficiently in detail.
4. The effect of melatonin treatment before sleep on blood pressure and arterial stiffness: a three-month randomized placebo-controlled crossover study in patients with type 2 diabetes.
About the work.
The study aims to evaluate the effect of melatonin on blood pressure and arterial stiffness in people with type 2 diabetes. In a randomized controlled trial, the effects of melatonin and placebo were compared over three months.
Results.
Melatonin did not have a significant effect on blood pressure or pulse wave velocity. Numerical but statistically insignificant reductions in mean nocturnal systolic and diastolic pressure were observed.
3. Pulmonary cold perception through club cells initiates thermogenesis in adipose tissue to improve conditions in obesity.
About the work.
The study investigates the role of the lungs in cold perception and its impact on metabolism. Using mouse models, the authors compared thermogenic activity in adipose tissue upon activation of the pulmonary cold perception system.
Results.
Activation of the pulmonary cold perception system through KCNK2 channels in club cells leads to increased expression and secretion of Irisin, stimulating thermogenesis in adipose tissue. Pharmacological activation of this pathway using fluoxetine infusion enhances thermogenesis and reduces obesity in mice.
2. Circulating plasma follistatin follows a 24-hour rhythm in healthy young men.
About the work.
The study aims to characterize the 24-hour rhythm of plasma follistatin in healthy young men. In an observational study, blood samples were taken every three hours.
Results.
Plasma follistatin exhibited a significant 24-hour rhythm (P < .001) with a relative amplitude of 18% and a peak at 11:50 AM. ANOVA confirmed a significant time effect, with differences between morning and evening levels.