TOP-5 studies on keto, low-carbohydrate diet, and intermittent fasting from 08.10.2026 - 08.17.2026
Early onset of euglycemic diabetic ketoacidosis after starting empagliflozin, triggered by acute influenza; Ketogenic diet suppresses synaptic activity; β-Hydroxybutyrate reduces neuronal excitability; Intermittent fasting reduces neuropathic pain and cognitive deficits; Meal timing affects cardiovascular and neuroendocrine physiology and disease risk.
5. Early onset of euglycemic diabetic ketoacidosis after starting empagliflozin, triggered by acute influenza and ketogenic diet.
About the work.
The study focuses on a case of early onset of euglycemic diabetic ketoacidosis (euDKA) in a type 2 diabetes patient after starting empagliflozin against the background of influenza and a ketogenic diet. It examines the factors contributing to the development of euDKA and the need to reconsider the diabetes diagnosis with low insulin requirements.
Results.
The patient exhibited high levels of β-hydroxybutyrate and metabolic acidosis despite minimal insulin needs. C-peptide levels were preserved, and antibodies to glutamic acid decarboxylase and islet cells were negative.
4. β-Hydroxybutyrate reduces neuronal excitability through GIRK channels.
About the work.
The study aims to investigate the molecular mechanisms linking metabolic state to seizure suppression via β-hydroxybutyrate (β-HB). The effects of β-HB on neuronal excitability and synaptic transmission in the hippocampus of mice were compared.
Results.
Administration of β-HB rapidly reduced the duration of status epilepticus. β-HB hyperpolarized granule cells of the dentate gyrus, increased action potential threshold, and reduced firing frequency. β-HB suppressed synaptic transmission to granule cells, leading to reduced population activity and neuronal excitability.
3. Ketogenic diet suppresses synaptic activity.
About the work.
The publication is dedicated to the topic: The ketogenic diet suppresses synaptic activity.
Results.
The publication does not have an available abstract in the source.
2. Intermittent fasting alleviates neuropathic pain and cognitive deficits through the Alistipes finegoldii-Hippurate-STING neuroimmune axis.
About the work.
The study aims to evaluate the impact of intermittent fasting on chronic pain and cognitive impairments, as well as to explore the mechanism related to microbiota and metabolites. The effects of intermittent fasting and the addition of live bacteria Alistipes finegoldii were compared in various chronic pain models.
Results.
Intermittent fasting reduces mechanical allodynia, thermal hyperalgesia, and cognitive impairments, as well as decreases anxious behavior. Strengthening the integrity of the intestinal barrier, reducing neuroinflammation, and altering the microbiota, with A. finegoldii as the most enriched species, were noted.