Nattokinase — an enzyme derived from the traditional Japanese fermented product natto. It is a serine protease that has the ability to break down fibrin — a protein involved in the formation of blood clots.
Due to this property, nattokinase helps improve blood circulation and reduce the risk of thrombosis, making it an important nutrient for supporting cardiovascular health.
Health Benefits
- supports normal blood viscosity, preventing the formation of clots;
- helps lower blood pressure and improve blood flow;
- has a mild anti-inflammatory effect, improving the condition of blood vessels;
- possesses antioxidant properties, protecting cells from oxidative stress;
- may help lower cholesterol levels and improve the elasticity of blood vessels;
- enhances the supply of oxygen and nutrients to tissues.
Mechanism of Action
The main action of nattokinase is related to the breakdown of fibrin — a key protein involved in the formation of clots. The enzyme activates plasminogen, converting it into plasmin, which dissolves fibrin clots.
Thus, nattokinase supports normal blood flow and reduces the load on blood vessels and the heart.
Additionally, it may lower the levels of inflammatory mediators and improve blood fluidity without significantly affecting platelets.
Daily Requirement and Intake Recommendations
The optimal dose of nattokinase depends on health status and the purpose of use, but it usually ranges from 100–200 mg per day.
It is recommended to take the supplement on an empty stomach, drinking plenty of water to ensure maximum absorption.
Intake recommendations:
- start with a minimal dose and gradually increase if necessary;
- do not combine with anticoagulants or aspirin without consulting a doctor;
- prefer supplements containing pure nattokinase without unnecessary additives;
- consult a specialist for chronic conditions.
Symptoms and Consequences of Deficiency
Nattokinase is not an essential nutrient; however, enzymatic activity similar to its action is important for the normal condition of blood vessels.
A lack of enzymatic activity in the body may contribute to increased blood viscosity, a tendency to edema, varicose veins, and slow tissue recovery after inflammation and injuries.
Possible Risks of Excess and Their Manifestations
- increased risk of bleeding when exceeding the dose or combining with anticoagulants;
- gastrointestinal disorders (bloating, discomfort, diarrhea);
- allergic reactions in sensitive individuals;
- lowering blood pressure in people with hypotension.
Nattokinase — a natural enzyme with proven effects on fibrinolytic processes, but it requires caution when used.
It can be considered as a preventive measure for supporting blood vessels and circulation, but it is important to adhere to the dosage and take individual body characteristics into account.
Options on iHerb
| Product | Price, $ |
|---|---|
Arthur Andrew Medical, Nattovena, Pure Nattokinase, 4,000 FUs, 180 Capsules | 68.57 |
Nutricology, NattoZyme® Nattokinase, 100 mg (2,000 FU), 60 Softgels | 56.46 |
NOW Foods, Nattokinase, 100 mg, 60 Veg Capsules | 20.06 |
NOW Foods, Nattokinase, 100 mg, 120 Veg Capsules | 33.80 |
Probase Nutrition, Nattokinase, 120 Capsules (100 mg per Capsule) | 23.19 |
Primaforce, Nattokinase, 100 mg, 120 Capsules | 14.46 |
Source Naturals, NSK-SD Nattokinase, 100 mg, 30 Capsules | 14.71 |
Swanson, Nattokinase, 100 mg , 30 Capsules | 11.56 |
Swanson, Nattokinase, 200 mg, 30 Capsules | 21.73 |
Vitamatic, Nattokinase, 120 DRcaps® Hypromellose Capsules (100 mg per Capsule) | 14.49 |