TOP-5 studies on keto, low-carb diets, and intermittent fasting from 12.05.2026 - 19.05.2026
Improvement of motor behavior, anxiety, and inflammation of the cerebellum; Disruption of the BMAL1-FGF21 signaling pathway in the liver and metabolic consequences; Ketogenic diet therapy for children with super-refractory status epilepticus in intensive care; Pigmentary prurigo; IL-6 signaling in the ventromedial hypothalamus mediates excessive aggression induced by sleep deprivation in late gestation in male mice.
5. Ketogenic diet improves motor and anxiety behaviors, as well as cerebellar inflammation through axonal myelination in a BTBR autism mouse model.
About the work.
The study aimed to evaluate the impact of a ketogenic diet on motor and anxiety behaviors, as well as cerebellar inflammation in BTBR autism model mice. The effects of a standard diet and a ketogenic diet on behavioral and biochemical parameters were compared.
Results.
The ketogenic diet improved motor deficits and anxiety behavior in BTBR mice, which was manifested by a significant increase in tests for motor activity and anxiety. There was also a decrease in pro-inflammatory cytokines and improvement in axonal myelination.
4. Disruption of the BMAL1-FGF21 signaling pathway in the liver leads to adverse metabolic consequences of the ketogenic diet.
About the work.
The study aimed to elucidate the mechanisms determining the different metabolic responses to the ketogenic diet (KD) in mice and patients with alcoholic fatty liver disease. Metabolic outcomes were compared between wild-type mice and mice with impaired FGF21 and BMAL1 function.
Results.
The ketogenic diet over 8 weeks leads to weight loss and maintenance of metabolic homeostasis in wild-type mice but causes weight gain and worsened lipid metabolism in db/db mice. db/db mice exhibit reduced sensitivity to FGF21 due to BMAL1 deficiency, leading to KD intolerance. Supplementation with FGF21 improves lipid dysregulation.
3. Ketogenic dietary therapy for children with super-refractory status epilepticus in the intensive care unit: international clinical guidelines.
About the work.
The aim of the study was to create practical recommendations for medical teams on initiating ketogenic diet therapy for children with super-refractory status epilepticus in intensive care settings. The study conducted a literature review and a survey to achieve consensus on the recommendations.
Results.
25 statements were formulated, of which 30 met the criteria for key recommendations. The recommendations cover patient selection, treatment preparation, diet prescription, diet initiation, monitoring of side effects, fine-tuning, and discontinuation of the ketogenic diet.
2. Pigmentary prurigo-like dermatitis associated with the ketogenic diet.
About the work.
The publication is dedicated to the topic: Pigmentary pruritus associated with the ketogenic diet.
Results.
The publication does not have an available abstract in the source.