TOP-5 studies on obesity, diabetes, and insulin resistance from 26.05.2026 - 02.06.2026
Identification of promising practices in lifestyle change programs for prediabetic populations: meta-analysis and meta-regression of randomized controlled trials; 12-week fisetin supplementation and interval strength training with aerobic load: changes in Maresin-1 and inflammatory markers in men with obesity: randomized controlled trial; Mitigation of adaptive thermogenesis with culinary doses of red pepper under 24-hour negative energy balance; Unveiling the IL-17 axis: an immunometabolic bridge between psoriasis and metabolic syndrome; Navigating nutrition in a 24/7 world: a review of dietary intake and chrono-nutrition assessments in shift-working populations.
5. Identification of promising practices in lifestyle intervention programs for prediabetic populations: meta-analysis and meta-regression of randomized controlled trials.
About the work.
The aim of the study was to summarize current data on the relationship between participant characteristics, intervention components, and the effect of lifestyle change programs for people with prediabetes. The study analyzed randomized controlled trials comparing interventions with usual care or no intervention.
Results.
Greater weight loss (%) was associated with larger reductions in diabetes incidence (β = 0.07 [0.02, 0.12], p = 0.010). Achieving ≥ 5% weight loss contributes to diabetes prevention.
4. 12-week fisetin supplementation and interval strength training with aerobic load: changes in Maresin-1 and inflammatory markers in men with obesity: randomized controlled study.
About the work.
The study aimed to evaluate the effect of adding fisetin to interval training on Maresin-1 levels and inflammatory markers in men with obesity. The randomized controlled trial compared four groups with different interventions.
Results.
Significant changes were observed in levels of Maresin-1, IL-6, TNF-α, FBS, insulin, and HOMA-IR. Maresin-1 increased in the TP and TF groups. IL-6 decreased in the T, TF, and F groups. TNF-α decreased in all intervention groups. Levels of FBS, insulin, and HOMA-IR significantly decreased in all active groups, with the largest reductions in the TF group.
3. Mitigation of adaptive thermogenesis with culinary doses of red pepper under 24-hour negative energy balance.
About the work.
The study aimed to evaluate the effect of culinary doses of capsaicin from red pepper on adaptive thermogenesis and satiety under negative energy balance conditions. Data from 24 randomized controlled trials were analyzed.
Results.
Culinary doses of capsaicin do not prevent adaptive thermogenesis but may mitigate its effects under negative energy balance, especially when combined with protein. Increased fat oxidation and improved satiety suggest potential benefits for maintaining weight loss.
2. Unveiling the IL-17 axis: an immunometabolic bridge between psoriasis and metabolic syndrome.
About the work.
This review focuses on the relationship between psoriasis and metabolic syndrome, emphasizing the role of the interleukin-17 (IL-17) signaling pathway in these processes.