Blocked Neurons, Susan Thompson, 2017
This book is dedicated to the problem of excess weight and overeating. It explains why most people fail to lose weight and maintain results despite diets and willpower efforts. The author shows that the root of the problem lies in the brain's functioning: it perceives weight loss as a threat to survival and triggers biological defense mechanisms—intensified hunger, cravings for food, and sabotage of any restrictions. The book thoroughly examines why willpower doesn't work, how stress and chaotic eating block self-regulation, and what conditions allow to "calm" the brain and regain control over eating behavior.
The author's final conclusion is that sustainable weight loss is only possible with a systemic approach focused on neurobiology, rather than on prohibitions: when the brain stops fighting, the body begins to lose weight on its own, and the result becomes long-term.
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Part 1. How the Brain Hinders Our Weight Loss
The brain perceives weight loss not as an improvement in health, but as a threat to survival. It is evolutionarily programmed to protect energy reserves, so when trying to lose weight, it automatically activates protective mechanisms: it increases hunger, lowers energy levels, slows metabolism, and increases cravings for calorie-dense foods.
The hypothalamus plays a key role—it is the center for regulating appetite and energy balance. Under chronic stress, inflammation, insulin resistance, and leptin dysfunction, the brain fails to adequately read satiety signals. As a result, even with an excess of fat, the body feels "starved."
Stress is one of the main blockers of weight loss. Elevated cortisol levels cause the brain to conserve energy, retain fat (especially visceral fat), and seek quick sources of glucose. Diets based on strict restrictions only exacerbate this effect, reinforcing a vicious cycle.
The author emphasizes that the problem of excess weight is not a matter of willpower. It is the result of neurobiological disruptions: impaired neuroplasticity, energy deficits in neurons, and distorted hormonal feedback. As long as the brain is in threat mode, sustainable weight loss is impossible.
The conclusion of this part: to lose weight, it is necessary to first "calm" the brain—reduce stress and inflammation, restore sensitivity to leptin and insulin, and return the brain to a sense of safety. Without this, any diets will be perceived as an attack on survival.
Part 2. Reasonable Nutrition – A Bridge Over the Abyss of Willpower
Willpower is not a reliable tool for controlling nutrition. The author shows that attempts to eat "correctly" through self-control are doomed to fail if the brain is in a state of energy deficit, stress, or inflammation. In such conditions, the prefrontal cortex, responsible for decision-making, literally shuts down, yielding control to more primitive survival centers.
"Reasonable nutrition" is understood not as a diet or a system of prohibitions, but as a way to feed the brain so that it does not have to constantly struggle with hunger and anxiety. Sufficient amounts of protein, fats, micronutrients, and stable glucose levels create a sense of safety, which naturally reduces the urge to overeat.
When the brain receives everything it needs, the need for constant willpower disappears. A person stops perceiving food as a reward or comfort because the neurotransmitter systems (dopamine, serotonin) begin to operate stably, rather than in deficit mode.
The author emphasizes that strict restrictions only deepen the gap between rational intention and actual behavior. "Reasonable" nutrition, on the contrary, serves as a bridge: it reduces the load on the nervous system and restores control over food choices without self-violence.
The conclusion of this part: sustainable changes in nutrition are only possible when the brain stops fighting for survival. Properly structured nutrition replaces willpower with physiological resilience.
Part 3. Roadmap: At the Start
At the start of changes, it is important not to "break" oneself, but to create conditions under which the brain stops resisting. The author emphasizes that sharp interventions—strict diets, intense workouts, simultaneous changes in all habits—are perceived by the nervous system as a threat and trigger a backlash.
The first stage of the roadmap is stabilization. It includes normalizing sleep, regular meal times, and eliminating obvious nutrient deficiencies. Without this, the brain cannot exit survival mode, and any further steps will be ineffective.
Special attention is given to rhythms. Irregular eating, late bedtimes, and constant glucose fluctuations create chaos for the hypothalamus. Restoring predictability of signals is key to reducing anxiety and impulsive eating behavior.
The author suggests starting with minimal but sustainable changes that the brain can accept without resistance. This creates a sense of control and safety, gradually increasing neuroplasticity and readiness for the next stages.
The conclusion of this part: the start is not a leap, but leveling the foundation. Until sleep, rhythms, and basic brain physiology are restored, any attempts to lose weight will be premature.
Part 4. Roadmap: Staying the Course
At the stage of maintaining the course, the key task is to prevent the brain from returning to threat mode. After initial stabilization, the body begins to test changes for "strength": sensitivity to stress increases, and fluctuations in appetite and mood may occur. This is not a backlash, but a normal adaptive response of the nervous system.
The author emphasizes the importance of consistency rather than perfection. Regular meals, predictable physical activity, and stable sleep continue to send the brain signals of safety. It is the repetition, not the strictness, that solidifies new neural connections.
Special attention is given to stress management. Even with proper nutrition, chronic psycho-emotional tension can block neuroplasticity again and slow down weight loss. Therefore, the roadmap includes simple but systematic recovery practices: pauses, breathing, and reducing sensory overload.
As the condition stabilizes, gentle complexity becomes possible—moderate calorie reduction, increased physical activity, and working with habits. These steps are only acceptable when the brain does not perceive them as deprivation.
The conclusion of this part: staying the course is about maintaining a sense of safety and predictability. As long as the brain is calm, changes are automatically consolidated and do not require constant control.
Part 5. At the Goal: How to Stay in Shape
Reaching the desired weight is not the end, but a transition to a new regulatory mode. The author emphasizes that the main mistake at this stage is returning to old control strategies: strict restrictions, constant self-monitoring, and fear of "slipping." For the brain, this is again a signal of threat, capable of triggering reverse processes.
Staying in shape means maintaining the conditions under which weight normalizes itself: stable hormone function, adequate sensitivity to hunger and satiety, and preserved neuroplasticity. When the brain does not experience deficits, it naturally maintains energy balance effortlessly.
Flexibility is more important than discipline. The author emphasizes that fluctuations in weight, appetite, and activity are inevitable and physiological. The ability to adapt to changes without entering punishment mode is a key factor for long-term results.
Maintaining shape is built around lifestyle rather than dietary rules: sleep, movement, recovery, reducing chronic stress, and adequate nutrient saturation. In this state, food ceases to be a source of control or anxiety and becomes part of normal self-regulation.
The conclusion of this part: stable shape is a byproduct of a healthy brain. When neural networks operate freely, the body naturally maintains weight without struggle and willpower.
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