Serrapeptase (serrapeptidase) — a proteolytic enzyme discovered in the 1960s and extracted from the bacterium Serratia marcescens, which inhabits the intestines of the mulberry silk moth.
It belongs to serine proteases capable of breaking down protein structures, including pathological deposits, fibrosis, and biofilms.
It has been used in medicine since the 1970s, primarily in Japan, and is utilized as an anti-inflammatory, proteolytic, thrombolytic, and antimicrobial agent.
Benefits and Mechanisms of Action
Serrapeptase breaks down the protein-polysaccharide matrix of biofilms, facilitating access for antibiotics and immune cells to pathogens. This makes it promising for chronic infections associated with biofilms (sinusitis, osteomyelitis, chronic bronchitis, arthritis, acne).
It reduces inflammation, thins mucus, improves microcirculation, and promotes tissue healing after injuries and surgeries.
In the blood, the enzyme lowers fibrinogen levels, dissolves clots, and improves blood rheology.
In tissues, it aids in the resorption of edema and pathological protein accumulations.
Indications and Use
- chronic inflammatory diseases of the respiratory tract;
- pathologies with biofilms and resistant infections;
- fibrosis, cysts, adhesions;
- cardiovascular diseases with fibrinous and atherosclerotic formations;
- support in neurodegenerative pathologies with amyloid deposits.
Doses and Forms of Release
For systemic action, serrapeptase is taken on an empty stomach, without opening the capsule.
Clinical protocols use doses of 120–250 thousand SPU per day, and in acute conditions — up to 2–2.25 million SPU.
Forms of release include monoproducts and complex formulas with other enzymes (natokinase, bromelain, cellulase), which expands the spectrum of action on various components of biofilms.
Combination with Other Nutrients
- curcumin — enhances anti-inflammatory and antiproliferative effects;
- vitamins D3 and K2 — support bone health and prevent vascular calcification;
- omega-3 and MCT — reduce inflammation and support brain function.
Risks and Contraindications
- peptic ulcer disease of the stomach or intestines;
- coagulation disorders;
- use of anticoagulants without medical supervision;
- pregnancy and breastfeeding;
- severe liver or kidney failure.
Allergic reactions, gastrointestinal discomfort, and increased bleeding may occur.
A consultation with a doctor and compatibility check with other medications are necessary before starting the course.
