TOP-5 studies on keto, low-carbohydrate diet, and intermittent fasting from 05.25.2026 - 06.01.2026
The ketogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges; Very low-carbohydrate ketogenic diet in women with endometrial cancer and overweight, previously untreated: a randomized feasibility study; The ketogenic diet may regulate autophagy in mesenchymal stem cells; Can targeting the gut microbiome become a new treatment option for intermittent claudication?; The regulatory influence of intermittent fasting on autophagy in structural and cognitive brain impairments induced by a high-fat diet in rats.
5. Can targeting the gut microbiome become a new treatment option for intermittent claudication?
About the work.
The study aims to evaluate the potential of using the gut microbiome as a new treatment method for intermittent claudication. Various dietary interventions and their impact on microbial balance are considered.
Results.
The available abstract does not describe the results in sufficient detail.
4. The ketogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges.
About the work.
The review explores the molecular mechanisms through which the ketogenic diet may protect against neurodegeneration, including the use of ketone bodies and reduction of oxidative stress. Potential benefits of the diet for various neurodegenerative diseases are discussed.
Results.
The available abstract does not describe the results in sufficient detail.
3. Very low-carbohydrate ketogenic diet in women with endometrial cancer and overweight, previously untreated: a randomized feasibility study.
About the work.
The study aims to assess the feasibility of a very low-carbohydrate diet in overweight women with endometrial cancer. Participants were randomized to receive either a very low-carbohydrate diet or a standard diet for 21-28 days.
Results.
Fifteen participants completed the study, with 91 ± 4% of VLCD meals consumed, a weight loss of 5.5 ± 0.8%, and no serious adverse effects. Glucose and insulin levels decreased by 22 ± 5.9% and 60 ± 3.8%, respectively, while total cholesterol and low-density lipoproteins increased by 6 ± 2.7% and 17.8 ± 8.9%. RNA-Seq showed enrichment of CD8 + T-cells, confirmed by immunohistochemical analysis.
2. The ketogenic diet may regulate autophagy in mesenchymal stem cells through the mTOR signaling pathway, contributing to osteoporosis in mice.
About the work.
The study aims to evaluate the effect of rapamycin on osteoporosis induced by the ketogenic diet and to elucidate the mechanisms of this effect. Changes in bone microstructure and levels of various biomarkers were compared in mice receiving the ketogenic diet and rapamycin.
Results.
The ketogenic diet and ovariectomy led to significant bone mass loss. The ketogenic diet decreased ALP levels and increased TRAP in serum, as well as caused changes in osteocalcin expression and autophagy. Rapamycin reduced bone mass loss, increased ALP levels, and decreased TRAP, while also regulating osteocalcin expression and autophagy.