TOP-5 Studies on Biohacking and Longevity from July 10, 2026 - July 17, 2026
The link between circadian rhythm disturbances and cognitive decline in older adults; The impact of timing on bright light therapy: alleviating anhedonia and circadian rhythm disturbances in patients with depression: a randomized controlled trial; Long-term safety and efficacy of intracortical microstimulation in humans; The relationship between sleep disorders and adipokine secretion profiles: new mechanisms of metabolic disease risk; Chronic infection and heart aging: a new perspective on pathogen-associated cardiomyopathy.
5. The link between circadian rhythm disturbances and cognitive decline in older adults: a systematic review.
About the study.
The study aims to analyze the relationship between circadian rhythm disturbances and cognitive decline in older adults over 60 years old. Various aspects of circadian dysfunction and their impact on the development or progression of mild cognitive impairment and dementia were considered.
Results.
Circadian dysregulation was consistently associated with an increased risk of developing or progressing mild cognitive impairment and dementia.
4. The impact of timing on bright light therapy: alleviating anhedonia and circadian rhythm disturbances in patients with depression: a randomized controlled trial.
About the study.
The study aims to evaluate the effectiveness of different timing regimes of bright light therapy for alleviating anhedonia and circadian rhythm disturbances in patients with depression. Results were compared between groups receiving light therapy in the morning and evening.
Results.
The morning light therapy groups showed significant improvement on the anhedonia scale (RPAS) and a delay in melatonin peak compared to placebo. A correlation was observed between changes in RPAS and the phase of melatonin peak (P = 0.048). Depression symptoms improved after both morning and evening light therapy.
3. Long-term safety and efficacy of intracortical microstimulation in humans.
About the study.
The study aims to assess the safety and efficacy of intracortical microstimulation (ICMS) in individuals with spinal cord injury. The clinical trial evaluated the outcomes of ICMS in five participants with implanted microelectrode arrays.
Results.
More than 168 million ICMS pulses were delivered without serious adverse effects. ICMS consistently elicited sensations localized to the hand, and 64 ± 13% of electrodes continued to reliably evoke tactile sensations after 10 years.
2. The relationship between sleep disorders and adipokine secretion profiles: new mechanisms of metabolic disease risk.
About the study.
The review focuses on the relationship between sleep disorders and metabolic diseases, emphasizing the role of dysregulation of adipokine secretion. Mechanisms through which sleep disturbances affect metabolic health are discussed.
Results.
Sleep disturbances lead to dysregulation of leptin and reduced levels of adiponectin, while obstructive sleep apnea causes increased IL-6 and ANGPTL4. These changes contribute to insulin resistance, dyslipidemia, and chronic low-grade inflammation, increasing the risk of metabolic diseases.