5-methyltetrahydrofolate, or the most biologically active form of folic acid (vitamin B9), plays a key role in amino acid metabolism and DNA synthesis.
It is important for maintaining the health of the nervous system and ensuring the normal functioning of cells. In addition, 5-methyltetrahydrofolate plays an important role in fat metabolism processes, making it particularly valuable on a ketogenic diet.
On a ketogenic diet, it is important to ensure adequate intake of folates through food, as some sources, such as whole grains and fruits, are limited in the diet.
Fish, meat, leafy green vegetables, avocados, and nuts contain sufficient amounts of folates, including 5-methyltetrahydrofolate. Therefore, if you consume enough of these foods, there is no need for additional intake of 5-methyltetrahydrofolate.
Health Benefits
Involvement in methylation. 5-methyltetrahydrofolate is necessary for methylation, a process that affects gene expression and can regulate numerous biochemical reactions in the body.
Nervous system health. It is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, making it important for mental health.
Deficiency can lead to homocysteine. A deficiency of 5-methyltetrahydrofolate can cause the accumulation of homocysteine, which is associated with an increased risk of cardiovascular diseases.
Energy levels. It may help boost energy levels and reduce fatigue, especially in people with folate deficiency.
Depression. Some studies show that low levels of 5-methyltetrahydrofolate may be associated with an increased risk of depression and other mental disorders.
5-methyltetrahydrofolate is used in the treatment of depressive disorders and autism spectrum disorders.
Antioxidant properties. It has some antioxidant properties, helping to protect cells from oxidative stress.
Amino acid metabolism. This metabolite is also involved in the metabolism of amino acids such as methionine, playing an important role in protein synthesis.
Interesting Facts about 5-methyltetrahydrofolate
Role in pregnancy. This metabolite is important for women during pregnancy, as it helps prevent neural tube defects in the fetus.
Supplement forms. 5-methyltetrahydrofolate is available in supplement form, which is often recommended for people with folate metabolism disorders.
Synthesis in the body. 5-methyltetrahydrofolate is formed from folate by the enzyme methylene-tetrahydrofolate reductase (MTHFR), which plays a key role in its metabolism.
Genetic mutations. Some people have mutations in the MTHFR gene, which can lead to reduced ability to convert folate into 5-methyltetrahydrofolate.
Comparison with regular folate. 5-methyltetrahydrofolate is more bioavailable than folic acid, making it a preferred choice for some people.
Recommended doses. The recommended dose of 5-methyltetrahydrofolate in supplements can vary, but often ranges from 400 to 1000 mcg per day.
Resistance to degradation. 5-methyltetrahydrofolate is more resistant to degradation than folic acid, making it preferable for use in supplements and functional products.
