Threonine

Necessary for the synthesis of collagen and immunoglobulins. Deficiency results in weak immunity and digestive disorders. Prescribed for digestive issues and weakened immunity.
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Essential amino acid:
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Threonine — one of the essential amino acids that is not synthesized in the body and must be obtained from food.

It is involved in protein synthesis, the formation of collagen and elastin, supports skin and connective tissue health, contributes to the formation of antibodies necessary for the immune system, and also plays an important role in the metabolism of fats and carbohydrates.

To maintain optimal threonine levels, it is important to consider its dietary sources and adhere to the recommended intake. Both a deficiency and an excess of threonine can lead to various disorders in the body’s functioning.

Health Benefits

Threonine is involved in several vital processes:

  • it is a component of structural proteins such as collagen and elastin;
  • it contributes to the production of antibodies and supports immunity;
  • it participates in the synthesis of neurotransmitters and supports the nervous system;
  • it regulates fat and carbohydrate metabolism;
  • it supports liver health and normal digestion.

Daily Requirement and Sources

The recommended daily intake of threonine is:

  • for adults — 20–30 mg per kg of body weight;
  • for children and adolescents — up to 30 mg per kg of body weight;
  • in conditions of stress or increased physical activity — the requirement may increase.

The main sources of threonine are:

Possible forms and their learnability

Nutrient forms are listed from best to worst:

L-threonine. Biologically active and well-absorbed form, necessary for the synthesis of collagen, elastin, mucous membranes, and immune proteins. Used in nutrition science to support the gastrointestinal tract, liver, and tissue regeneration.
D-threonine. Does not participate in human metabolism, is not incorporated into proteins. Not used in supplements and nutrition.

Symptoms and Consequences of Deficiency

A deficiency of threonine can lead to disorders in various body systems:

  • deterioration of skin, hair, and connective tissue condition;
  • decreased immunity and frequent infections;
  • slowed metabolism and digestive issues;
  • muscle weakness and dystrophy;
  • increased fatigue, anxiety, and depressive states.

Possible Risks of Excess and Their Manifestations

Excessive threonine intake, especially from supplements, can cause:

  • amino acid imbalance (e.g., decreased levels of methionine and leucine);
  • digestive disorders (nausea, diarrhea);
  • overload of the liver and kidneys;
  • allergic reactions;
  • metabolic disorders.

Consuming threonine up to 30 mg per kg of body weight per day is considered safe.


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Amino acids
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